anti-ABCA1 antibody [5A1-1422] (FITC)

Key features and details

  • 产品描述: FITC-conjugated Rat Monoclonal antibody [5A1-1422] recognizes ABCA1.Rat anti Mouse ABCA1 antibody, clone 5A1-1422 recognizes murine adenosine triphosphate (ATP) Binding cassette transporter 1 (ABCA1). The ABC transporters are a large family of conserved proteins that transport a wide variety of molecules across cellular membranes. ABCA1 is a member of the ABC-A sub-family, which acts as a lipid translocator. The molecule was originally identified as a scavenger receptor on macrophages and research shows that ABCA1 also plays a major role in cholesterol metabolism. ABCA1 may play an important role in protecting against cardiovascular disease.Mutations in ABCA1 gene have been associated with Tangiers disease, a genetic disorder of lipid metabolism, and familial high density lipoprotein (HDL) deficiency.
  • 反应物种: Ms
  • 应用: FACS
  • 宿主: Rat
  • 克隆: Monoclonal
  • 克隆号: 5A1-1422
  • 同位型: IgG2a
  • 靶点名称: ABCA1
  • 抗原物种: Mouse
  • Brand:
CAT.NO. : ARG23548
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Product Details
概述
产品描述FITC-conjugated Rat Monoclonal antibody [5A1-1422] recognizes ABCA1.
Rat anti Mouse ABCA1 antibody, clone 5A1-1422 recognizes murine adenosine triphosphate (ATP) Binding cassette transporter 1 (ABCA1). The ABC transporters are a large family of conserved proteins that transport a wide variety of molecules across cellular membranes. ABCA1 is a member of the ABC-A sub-family, which acts as a lipid translocator. The molecule was originally identified as a scavenger receptor on macrophages and research shows that ABCA1 also plays a major role in cholesterol metabolism. ABCA1 may play an important role in protecting against cardiovascular disease.Mutations in ABCA1 gene have been associated with Tangiers disease, a genetic disorder of lipid metabolism, and familial high density lipoprotein (HDL) deficiency.
反应物种Ms
应用FACS
宿主Rat
克隆Monoclonal
克隆号5A1-1422
同位型IgG2a
靶点名称ABCA1
抗原物种Mouse
抗原ABCA1 transfected HeLa cells.
偶联标记FITC
別名TGD; Cholesterol efflux regulatory protein; HDLDT1; ATP-binding cassette sub-family A member 1; ATP-binding cassette 1; ATP-binding cassette transporter 1; ABC-1; ABC1; CERP
应用说明
应用建议
应用推荐稀释比
FACS1:10 - 1:200
应用说明FACS: Use 10 µl of the suggested working dilution to label 10^6 cells in 100 µl.
* The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.
属性
形式Liquid
纯化Purification with Protein G.
缓冲液PBS, 0.09% Sodium azide and 1% BSA.
抗菌剂0.09% Sodium azide
稳定剂1% BSA
浓度0.1 mg/ml
存放说明Aliquot and store in the dark at 2-8°C. Keep protected from prolonged exposure to light. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
注意事项For laboratory research only, not for drug, diagnostic or other use.
生物信息
数据库连接

GeneID: 11303 Mouse ABCA1

Swiss-port # P41233 Mouse ATP-binding cassette sub-family A member 1

基因名称ABCA1
全名ATP-binding cassette, sub-family A (ABC1), member 1
背景介绍The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intracellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ABC1 subfamily. Members of the ABC1 subfamily comprise the only major ABC subfamily found exclusively in multicellular eukaryotes. With cholesterol as its substrate, this protein functions as a cholesteral efflux pump in the cellular lipid removal pathway. Mutations in this gene have been associated with Tangier's disease and familial high-density lipoprotein deficiency. [provided by RefSeq, Jul 2008]
生物功能cAMP-dependent and sulfonylurea-sensitive anion transporter. Key gatekeeper influencing intracellular cholesterol transport. [UniProt]
预测分子量254 kDa
翻译后修饰Phosphorylation on Ser-2054 regulates phospholipid efflux.

Palmitoylation by DHHC8 is essential for membrane localization. [UniProt]
检测图片 (1)
  • ARG23548 anti-ABCA1 antibody [5A1-1422] (FITC) FACS image

    Flow Cytometry: pCPT-cAMP stimulated RAW264.7 cells stained with ARG23548 anti-ABCA1 antibody [5A1-1422] (FITC).

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