anti-ABCB4 / MDR3 antibody
Key features and details
- 产品描述:
- 反应物种:
- 应用:
- 宿主:
- 克隆:
- 同位型:
- 靶点名称:
- 抗原物种:
- 抗原:
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Brand:
CAT.NO. : ARG10766
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Size:
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Product Details
概述
| 产品描述 | Rabbit polyclonal antibody recognizes ABCB4 / MDR3 |
|---|---|
| 反应物种 | Hu, Ms, Rat |
| 应用 | FACS, WB |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | ABCB4 / MDR3 |
| 抗原物种 | Human |
| 抗原 | Partial recombinant protein around aa. 601-720 of Human ABCB4 / MDR3. |
| 偶联标记 | Un-conjugated |
| 別名 | ATP-binding cassette sub-family B member 4; P-glycoprotein 3; ABC21; PGY3; MDR3; MDR2; MDR2/3; Multidrug resistance protein 3; EC 3.6.3.44; PFIC-3; GBD1; ICP3 |
应用说明
| 应用建议 |
| ||||||
|---|---|---|---|---|---|---|---|
| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Affinity purification with immunogen. |
| 缓冲液 | PBS, 0.025% Sodium azide and 2.5% BSA. |
| 抗菌剂 | 0.025% Sodium azide |
| 稳定剂 | 2.5% BSA |
| 浓度 | 0.5 mg/ml |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | ABCB4 |
| 全名 | ATP-binding cassette, sub-family B (MDR/TAP), member 4 |
| 背景介绍 | The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance as well as antigen presentation. This gene encodes a full transporter and member of the p-glycoprotein family of membrane proteins with phosphatidylcholine as its substrate. The function of this protein has not yet been determined; however, it may involve transport of phospholipids from liver hepatocytes into bile. Alternative splicing of this gene results in several products of undetermined function. [provided by RefSeq, Jul 2008] |
| 生物功能 | Mediates ATP-dependent export of organic anions and drugs from the cytoplasm. Hydrolyzes ATP with low efficiency. Not capable of conferring drug resistance. Mediates the translocation of phosphatidylcholine across the canalicular membrane of the hepatocyte. [UniProt] |
| 预测分子量 | 142 kDa |
| 翻译后修饰 | Phosphorylated (PubMed:24723470). Phosphorylation on Thr-34 is required for PC efflux activity. Phosphorylation occurs on serine and threonine residues in a protein kinase A- or C-dependent manner (PubMed:24723470). May be phosphorylated on Thr-44 and Ser-49 (PubMed:24723470). Glycosylated (PubMed:17523162, PubMed:24723470, PubMed:21820390). |
检测图片 (3)
ARG10766 anti-ABCB4 / MDR3 antibody IHC-P image
Immunohistochemistry: Human liver tissue stained with ARG10766 anti-ABCB4 / MDR3 antibody.
ARG10766 anti-ABCB4 / MDR3 antibody WB image
Western blot:RH35 and Mouse liver tissue stained with ARG10766 anti-ABCB4 / MDR3 antibody.
ARG10766 anti-ABCB4 / MDR3 antibody FACS image
Flow Cytometry: HepG2 cells were blocked with 10% normal goat serum and then stained with ARG10766 anti-ABCB4 / MDR3 antibody (blue) at 1 µg/10^6 cells for 30 min at 20°C, followed by incubation with DyLight®488 labelled secondary antibody. Isotype control antibody (green) was rabbit IgG (1 µg/10^6 cells) used under the same conditions. Unlabelled sample (red) was also used as a control.
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