anti-ADSL / Adenylosuccinate Lyase antibody
Key features and details
- 产品描述:
- 反应物种:
- 应用:
- 宿主:
- 克隆:
- 同位型:
- 靶点名称:
- 抗原物种:
- 抗原:
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Brand:
CAT.NO. : ARG58337
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Product Details
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes ADSL / Adenylosuccinate Lyase |
|---|---|
| 反应物种 | Hu, Ms, Rat |
| 应用 | ICC/IF, WB |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | ADSL / Adenylosuccinate Lyase |
| 抗原物种 | Human |
| 抗原 | Recombinant fusion protein corresponding to aa. 1-310 of Human ADSL (NP_000017.1). |
| 偶联标记 | Un-conjugated |
| 別名 | ASASE; ASase; EC 4.3.2.2; Adenylosuccinase; Adenylosuccinate lyase; AMPS; ASL |
应用说明
| 应用建议 |
| ||||||
|---|---|---|---|---|---|---|---|
| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||
| 阳性对照 | Jurkat | ||||||
| 实际分子量 | 47 kDa |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Affinity purified. |
| 缓冲液 | PBS (pH 7.3), 0.02% Sodium azide and 50% Glycerol. |
| 抗菌剂 | 0.02% Sodium azide |
| 稳定剂 | 50% Glycerol |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | ADSL |
| 全名 | adenylosuccinate lyase |
| 背景介绍 | Adenylsuccinate lyase is involved in both de novo synthesis of purines and formation of adenosine monophosphate from inosine monophosphate. It catalyzes two reactions in AMP biosynthesis: the removal of a fumarate from succinylaminoimidazole carboxamide (SAICA) ribotide to give aminoimidazole carboxamide ribotide (AICA) and removal of fumarate from adenylosuccinate to give AMP. Adenylosuccinase deficiency results in succinylpurinemic autism, psychomotor retardation, and , in some cases, growth retardation associated with muscle wasting and epilepsy. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] |
| 生物功能 | Catalyzes two non-sequential steps in de novo AMP synthesis: converts (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate (SAICAR) to fumarate plus 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide, and thereby also contributes to de novo IMP synthesis, and converts succinyladenosine monophosphate (SAMP) to AMP and fumarate. [UniProt] |
| 预测分子量 | 55 kDa |
检测图片 (2)
ARG58337 anti-ADSL / Adenylosuccinate Lyase antibody ICC/IF image
Immunofluorescence: HeLa cells stained with ARG58337 anti-ADSL / Adenylosuccinate Lyase antibody.
ARG58337 anti-ADSL / Adenylosuccinate Lyase antibody WB image
Western blot: 25 µg of Jurkat cell lysate stained with ARG58337 anti-ADSL / Adenylosuccinate Lyase antibody at 1:1000 dilution.
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