anti-Angiopoietin 2 antibody

Key features and details

  • 产品描述: Rabbit Polyclonal antibody recognizes Angiopoietin 2
  • 反应物种: Hu, Ms, Rat
  • 应用: IHC-Fr, WB
  • 宿主: Rabbit
  • 克隆: Polyclonal
  • 同位型: IgG
  • 靶点名称: Angiopoietin 2
  • 抗原物种: Human
  • 抗原: Synthetic peptide of Human Angiopoietin 2.
  • Brand:
CAT.NO. : ARG41934
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Product Details
概述
产品描述Rabbit Polyclonal antibody recognizes Angiopoietin 2
反应物种Hu, Ms, Rat
应用IHC-Fr, WB
宿主Rabbit
克隆Polyclonal
同位型IgG
靶点名称Angiopoietin 2
抗原物种Human
抗原Synthetic peptide of Human Angiopoietin 2.
偶联标记Un-conjugated
別名ANG-2; Angiopoietin-2; ANG2; AGPT2
应用说明
应用建议
应用推荐稀释比
IHC-Fr1:50 - 1:200
WB1:500 - 1:2000
应用说明* The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.
阳性对照HUVEC
实际分子量~ 50 kDa
属性
形式Liquid
纯化Affinity purified.
缓冲液PBS (pH 7.4), 150 mM NaCl, 0.02% Sodium azide and 50% Glycerol.
抗菌剂0.02% Sodium azide
稳定剂50% Glycerol
存放说明For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
注意事项For laboratory research only, not for drug, diagnostic or other use.
生物信息
数据库连接

GeneID: 11601 Mouse ANGPT2

GeneID: 285 Human ANGPT2

GeneID: 89805 Rat ANGPT2

基因名称ANGPT2
全名angiopoietin 2
背景介绍The protein encoded by this gene is an antagonist of angiopoietin 1 (ANGPT1) and endothelial TEK tyrosine kinase (TIE-2, TEK). The encoded protein disrupts the vascular remodeling ability of ANGPT1 and may induce endothelial cell apoptosis. Three transcript variants encoding three different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
生物功能Binds to TEK/TIE2, competing for the ANGPT1 binding site, and modulating ANGPT1 signaling. Can induce tyrosine phosphorylation of TEK/TIE2 in the absence of ANGPT1. In the absence of angiogenic inducers, such as VEGF, ANGPT2-mediated loosening of cell-matrix contacts may induce endothelial cell apoptosis with consequent vascular regression. In concert with VEGF, it may facilitate endothelial cell migration and proliferation, thus serving as a permissive angiogenic signal. [UniProt]
细胞定位Secreted. [UniProt]
预测分子量57 kDa
检测图片 (1)
  • ARG41934 anti-Angiopoietin 2 antibody WB image

    Western blot: HUVEC cell lysate stained with ARG41934 anti-Angiopoietin 2 antibody.

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