anti-Annexin A5 antibody

Key features and details

  • 产品描述: Rabbit Polyclonal antibody recognizes Annexin A5
  • 反应物种: Hu, Ms, Rat, Dog, Hrs
  • 应用: ICC/IF, WB
  • 宿主: Rabbit
  • 克隆: Polyclonal
  • 同位型: IgG
  • 靶点名称: Annexin A5
  • 抗原物种: Human
  • 抗原: Recombinant full-length Human Annexin A5.
  • Brand:
CAT.NO. : ARG11135
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Product Details
概述
产品描述Rabbit Polyclonal antibody recognizes Annexin A5
反应物种Hu, Ms, Rat, Dog, Hrs
应用ICC/IF, WB
宿主Rabbit
克隆Polyclonal
同位型IgG
靶点名称Annexin A5
抗原物种Human
抗原Recombinant full-length Human Annexin A5.
偶联标记Un-conjugated
別名Placental anticoagulant protein 4; PAP-I; Thromboplastin inhibitor; Annexin V; ENX2; Lipocortin V; Anchorin CII; ANX5; Annexin-5; Annexin A5; VAC-alpha; CBP-I; PP4; HEL-S-7; Vascular anticoagulant-alpha; Endonexin II; Placental anticoagulant protein I; RPRGL3; Calphobindin I
应用说明
应用建议
应用推荐稀释比
ICC/IF1:2000 - 1:5000
WB1:10000 - 1:20000
应用说明* The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.
实际分子量~ 31 kDa
属性
形式Liquid
纯化Affinity purified.
缓冲液PBS, 5 mM Sodium azide and 50% Glycerol.
抗菌剂5 mM Sodium azide
稳定剂50% Glycerol
浓度1 mg/ml
存放说明For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
注意事项For laboratory research only, not for drug, diagnostic or other use.
生物信息
数据库连接

GeneID: 11747 Mouse ANXA5

GeneID: 25673 Rat ANXA5

GeneID: 308 Human ANXA5

基因名称ANXA5
全名annexin A5
背景介绍The Annexin 5 gene spans 29 kb containing 13 exons, and encodes a single transcript of approximately 1.6 kb and a protein product with a molecular weight of about 35 kDa.The protein encoded by this gene belongs to the annexin family of calcium-dependent phospholipid binding proteins some of which have been implicated in membrane-related events along exocytotic and endocytotic pathways. Annexin 5 is a phospholipase A2 and protein kinase C inhibitory protein with calcium channel activity and a potential role in cellular signal transduction, inflammation, growth and differentiation. Annexin 5 has also been described as placental anticoagulant protein I, vascular anticoagulant-alpha, endonexin II, lipocortin V, placental protein 4 and anchorin CII. Polymorphisms in this gene have been implicated in various obstetric complications. [provided by RefSeq, Dec 2019]
生物功能This protein is an anticoagulant protein that acts as an indirect inhibitor of the thromboplastin-specific complex, which is involved in the blood coagulation cascade. [UniProt]
预测分子量36 kDa
翻译后修饰S-nitrosylation is induced by interferon-gamma and oxidatively-modified low-densitity lipoprotein (LDL(ox)) possibly implicating the iNOS-S100A8/9 transnitrosylase complex. [UniProt]
检测图片 (2)
  • ARG11135 anti-Annexin A5 antibody ICC/IF image

    Immunofluorescence: HeLa cells grown under normal conditions (left) or treated with 15 mM Pentoxifyline for 24 hours (right). HeLa cells stained with ARG11135 anti-Annexin A5 antibody (red) at 1:3000 dilution, and co-stained with anti-beta Tubulin antibody (green) at 1:5000 dilution. Hoechst (blue) for nuclear staining.

    Annexin A5 is membrane associated and concentrated in blebs, and Pentoxifyline activates apoptosis and upregulates Annexin A5 expression.

  • ARG11135 anti-Annexin A5 antibody WB image

    Western blot: NIH/3T3, C6, HeLa, HEK293, Dog A72 and Horse NBL6 cell lysates stained with ARG11135 anti-Annexin A5 antibody at 1:10000 dilution.

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