anti-APC11 antibody
Key features and details
- 产品描述:
- 反应物种:
- 应用:
- 宿主:
- 克隆:
- 同位型:
- 靶点名称:
- 抗原物种:
- 抗原:
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Brand:
Product Details
| 产品描述 | Rabbit Polyclonal antibody recognizes APC11 |
|---|---|
| 反应物种 | Hu, Ms |
| 应用 | ICC/IF, IHC-P, WB |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | APC11 |
| 抗原物种 | Human |
| 抗原 | Recombinant fragment within a.a. 1-90 of Human APC11. |
| 偶联标记 | Un-conjugated |
| Protein Full name | Anaphase-promoting complex subunit 11 |
| 別名 | Hepatocellular carcinoma-associated RING finger protein; APC11; Cyclosome subunit 11; Apc11p; HSPC214; Anaphase-promoting complex subunit 11 |
| 应用建议 |
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|---|---|---|---|---|---|---|---|---|---|
| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||||
| 阳性对照 | Mouse heart | ||||||||
| 实际分子量 | 15-20 kDa |
| 形式 | Liquid |
|---|---|
| 纯化 | Affinity purified. |
| 缓冲液 | PBS, 0.01% Thiomersal and 50% Glycerol. |
| 抗菌剂 | 0.01% Thiomersal |
| 稳定剂 | 50% Glycerol |
| 浓度 | Batch dependent |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
| 数据库连接 | Swiss-port # Q9CPX9 Mouse Anaphase-promoting complex subunit 11 Swiss-port # Q9NYG5 Human Anaphase-promoting complex subunit 11 |
|---|---|
| 基因名称 | ANAPC11 |
| 全名 | anaphase promoting complex subunit 11 |
| 背景介绍 | Enables cullin family protein binding activity and ubiquitin-ubiquitin ligase activity. Contributes to ubiquitin-protein transferase activity. Involved in protein K11-linked ubiquitination. Located in nucleolus and nucleoplasm. Part of anaphase-promoting complex. [provided by Alliance of Genome Resources, Apr 2022] |
| 生物功能 | Together with the cullin protein ANAPC2, constitutes the catalytic component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. May recruit the E2 ubiquitin-conjugating enzymes to the complex. [UniProt] |
| 细胞定位 | Cytoplasm; Nucleus [UniProt] |
| 研究领域 | Cell Biology and Cellular Response antibody |
| 预测分子量 | 10 kDa |
| 翻译后修饰 | Auto-ubiquitinated. |
ARG43660 anti-APC11 antibody IHC-P image
Immunohistochemistry: Formalin-fixed and paraffin-embedded Human Liver tissue stained with ARG43660 anti-APC11 antibody at 1:150 dilution. Antigen Retrieval: Heat mediated was performed using 10 mM citrate buffer pH 6.0
ARG43660 anti-APC11 antibody IHC-P image
Immunohistochemistry: Formalin-fixed and paraffin-embedded Mouse Kidney tissue stained with ARG43660 anti-APC11 antibody at 1:150 dilution. Antigen Retrieval: Heat mediated was performed using 10 mM citrate buffer pH 6.0
ARG43660 anti-APC11 antibody WB image
Western blot: Mouse Heart tissue stained with ARG43660 anti-APC11 antibody at 1:1000 dilution.
ARG43660 anti-APC11 antibody ICC/IF image
Immunofluorescence: A549 cells stained with ARG43660 anti-APC11 antibody at 1:300 and 4°C. DAPI (blue) was used as the nuclear counter stain.
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