anti-Aquaporin 4 antibody
Key features and details
- 产品描述:
- 反应物种:
- 应用:
- 宿主:
- 克隆:
- 同位型:
- 靶点名称:
- 抗原物种:
- 抗原:
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Brand:
CAT.NO. : ARG22361
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Product Details
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes Aquaporin 4 |
|---|---|
| 反应物种 | Hu, Ms, Rat |
| 应用 | ICC/IF, IHC, WB |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | Aquaporin 4 |
| 抗原物种 | Rat |
| 抗原 | Synthetic peptide around the C-terminus of Rat Aquaporin 4. (N-CTKGSYMEVEDNRSQVETED) |
| 偶联标记 | Un-conjugated |
| 別名 | HMIWC2; Aquaporin-4; Mercurial-insensitive water channel; AQP-4; MIWC; WCH4 |
应用说明
| 应用建议 |
| ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Purification with Protein A. |
| 缓冲液 | PBS, 0.09% Sodium azide and 50% Glycerol |
| 抗菌剂 | 0.09% Sodium azide |
| 稳定剂 | 50% Glycerol |
| 浓度 | 1 mg/ml |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | Aqp4 |
| 全名 | aquaporin 4 |
| 背景介绍 | This gene encodes a member of the aquaporin family of intrinsic membrane proteins that function as water-selective channels in the plasma membranes of many cells. The encoded protein is the predominant aquaporin found in brain. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008] |
| 生物功能 | Forms a water-specific channel. Osmoreceptor which regulates body water balance and mediates water flow within the central nervous system. [UniProt] |
| 细胞定位 | Membrane |
| 预测分子量 | 35 kDa (unmodified); 50 kDa (glycosylated) |
| 翻译后修饰 | Phosphorylation by PKC at Ser-180 reduces conductance by 50%. Phosphorylation by PKG at Ser-111 in response to glutamats increases conductance by 40% (By similarity). |
检测图片 (2)
ARG22361 anti-Aquaporin 4 antibody IHC image
Immunohistochemistry: Rat kidney tissue stained with ARG22361 anti-Aquaporin 4 antibody (green) at 1:200 dilution.
ARG22361 anti-Aquaporin 4 antibody WB image
Western blot: Rat kidney inner medullary homogenates stained with ARG22361 anti-Aquaporin 4 antibody at 1:2000 dilution.
参考文献
AQP4 Attenuated TRAF6/NFκB Activation in Acrylamide-Induced Neurotoxicity
WB / Rat
Sevoflurane enhanced the clearance of Aβ1-40 in hippocampus under surgery via up-regulating AQP-4 expression in astrocyte.
WB, ICC/IF / Rat
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