anti-BAFF antibody
Key features and details
- 产品描述:
- 反应物种:
- 应用:
- 特异性:
- 宿主:
- 克隆:
- 同位型:
- 靶点名称:
- 抗原物种:
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Brand:
CAT.NO. : ARG54369
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Product Details
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes BAFF |
|---|---|
| 反应物种 | Hu, Ms, Rat |
| 应用 | ICC/IF, IHC-P, WB |
| 特异性 | This antibody recognizes human, mouse, and rat BAFF (approx. 38kDa). |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | BAFF |
| 抗原物种 | Human |
| 抗原 | Peptide corresponding to aa 254-269 at the C-terminus of human BAFF. |
| 偶联标记 | Un-conjugated |
| 別名 | BLYS; TALL1; Dendritic cell-derived TNF-like molecule; THANK; DTL; TNF- and APOL-related leukocyte expressed ligand 1; TNFSF20; CD257; BLyS; Tumor necrosis factor ligand superfamily member 13B; ZTNF4; CD antigen CD257; B lymphocyte stimulator; TALL-1; BAFF; B-cell-activating factor |
应用说明
| 应用建议 |
| ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||||
| 阳性对照 | HL60 |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Immunoaffinity chroma-tography |
| 缓冲液 | PBS (pH 7.4) and 0.02% Sodium azide |
| 抗菌剂 | 0.02% Sodium azide |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | Swiss-port # Q9WU72 Mouse Tumor necrosis factor ligand superfamily member 13B Swiss-port # Q9Y275 Human Tumor necrosis factor ligand superfamily member 13B |
|---|---|
| 基因名称 | TNFSF13B |
| 全名 | tumor necrosis factor (ligand) superfamily, member 13b |
| 背景介绍 | A novel member of the TNF superfamily was recently identified and designated BAFF (B Cell Activating Factor of the TNF Family) or BlyS (B Lymphocyte Stimulator), TALL-1 (TNF- and ApoL-Related Leukocyte-Expressed Ligand), and THANK (TNF Homologue that Activates Apoptosis, NF- B and c-jun N-terminal Kinase). BAFF is designated a B cell stimulator since it induces B cell proliferation and immunoglobulin secretion. BAFF and its receptors are involved in the development of systemic lupus erythematosus and other B cell-associated autoimmune diseases. |
| 生物功能 | Cytokine that binds to TNFRSF13B/TACI and TNFRSF17/BCMA. TNFSF13/APRIL binds to the same 2 receptors. Together, they form a 2 ligands -2 receptors pathway involved in the stimulation of B- and T-cell function and the regulation of humoral immunity. A third B-cell specific BAFF-receptor (BAFFR/BR3) promotes the survival of mature B-cells and the B-cell response. Isoform 2 seems to inhibit isoform 1 secretion and bioactivity. Isoform 3: Acts as a transcription factor for its own parent gene, in association with NF-kappa-B p50 subunit, at least in autoimmune and proliferative B-cell diseases. The presence of Delta4BAFF is essential for soluble BAFF release by IFNG/IFN-gamma-stimulated monocytes and for B-cell survival. It can directly or indirectly regulate the differential expression of a large number of genes involved in the innate immune response and the regulation of apoptosis. [UniProt] |
| 研究领域 | Cancer antibody; Cell Biology and Cellular Response antibody; Cell Death antibody; Immune System antibody |
| 预测分子量 | 31 kDa |
| 翻译后修饰 | The soluble form derives from the membrane form by proteolytic processing. Isoform 2 is not efficiently shed from the membrane unlike isoform 1. N-glycosylated. |
检测图片 (2)
ARG54369 anti-BAFF antibody IHC image
Immunohistochemistry: Human spleen stained with ARG54369 anti-BAFF antibody at 20 μg/ml dilution.
ARG54369 anti-BAFF antibody WB image
Western Blot: H:HL60;M: murine spleen tissue lysate stained with ARG54369 anti-BAFF antibody at 1 μg/ml dilution.
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