anti-BRIP1 antibody
Key features and details
- 产品描述:
- 反应物种:
- 应用:
- 宿主:
- 克隆:
- 同位型:
- 靶点名称:
- 抗原物种:
- 抗原:
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Brand:
CAT.NO. : ARG57350
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Size:
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Product Details
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes BRIP1 |
|---|---|
| 反应物种 | Hu |
| 应用 | WB |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | BRIP1 |
| 抗原物种 | Human |
| 抗原 | Recombinant Protein of Human BRIP1. |
| 偶联标记 | Un-conjugated |
| 別名 | BRCA1-interacting protein C-terminal helicase 1; ATP-dependent RNA helicase BRIP1; OF; BACH1; BRCA1-interacting protein 1; EC 3.6.4.13; Protein FACJ; BRCA1-associated C-terminal helicase 1; FANCJ; Fanconi anemia group J protein |
应用说明
| 应用建议 |
| ||||
|---|---|---|---|---|---|
| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||
| 阳性对照 | Mouse liver |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Affinity purification with immunogen. |
| 缓冲液 | PBS (pH 7.3), 0.02% Sodium azide and 50% Glycerol. |
| 抗菌剂 | 0.02% Sodium azide |
| 稳定剂 | 50% Glycerol |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | BRIP1 |
| 全名 | BRCA1 interacting protein C-terminal helicase 1 |
| 背景介绍 | The protein encoded by this gene is a member of the RecQ DEAH helicase family and interacts with the BRCT repeats of breast cancer, type 1 (BRCA1). The bound complex is important in the normal double-strand break repair function of breast cancer, type 1 (BRCA1). This gene may be a target of germline cancer-inducing mutations. [provided by RefSeq, Jul 2008] |
| 生物功能 | DNA-dependent ATPase and 5' to 3' DNA helicase required for the maintenance of chromosomal stability. Acts late in the Fanconi anemia pathway, after FANCD2 ubiquitination. Involved in the repair of DNA double-strand breaks by homologous recombination in a manner that depends on its association with BRCA1. [UniProt] |
| 预测分子量 | 141 kDa |
| 翻译后修饰 | Phosphorylated. Phosphorylation is necessary for interaction with BRCA1, and is cell-cycle regulated. Acetylation at Lys-1249 facilitates DNA end processing required for repair and checkpoint signaling. |
检测图片 (1)
ARG57350 anti-BRIP1 antibody WB image
Western blot: Mouse liver lysate stained with ARG57350 anti-BRIP1 antibody.
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