anti-CACNA2D2 antibody
Key features and details
- 产品描述:
- 反应物种:
- 应用:
- 宿主:
- 克隆:
- 同位型:
- 靶点名称:
- 抗原物种:
- 抗原:
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Brand:
CAT.NO. : ARG59870
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Product Details
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes CACNA2D2 |
|---|---|
| 反应物种 | Ms, Rat |
| 应用 | WB |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | CACNA2D2 |
| 抗原物种 | Human |
| 抗原 | Recombinant fusion protein corresponding to aa. 20-200 of Human CACNA2D2 (NP_001167522.1). |
| 偶联标记 | Un-conjugated |
| 別名 | CACNA2D; Voltage-gated calcium channel subunit alpha-2/delta-2; Voltage-dependent calcium channel subunit alpha-2/delta-2 |
应用说明
| 应用建议 |
| ||||
|---|---|---|---|---|---|
| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||
| 阳性对照 | Rat brain and Mouse brain | ||||
| 实际分子量 | 140 kDa |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Affinity purified. |
| 缓冲液 | PBS (pH 7.3), 0.02% Sodium azide and 50% Glycerol. |
| 抗菌剂 | 0.02% Sodium azide |
| 稳定剂 | 50% Glycerol |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | Swiss-port # Q6PHS9 Mouse Voltage-dependent calcium channel subunit alpha-2/delta-2 Swiss-port # Q8CFG6 Rat Voltage-dependent calcium channel subunit alpha-2/delta-2 |
|---|---|
| 基因名称 | CACNA2D2 |
| 全名 | calcium channel, voltage-dependent, alpha 2/delta subunit 2 |
| 背景介绍 | Calcium channels mediate the entry of calcium ions into the cell upon membrane polarization. This gene encodes the alpha-2/delta subunit of the voltage-dependent calcium channel complex. The complex consists of the main channel-forming subunit alpha-1, and auxiliary subunits alpha-2/delta, beta, and gamma. The auxiliary subunits function in the assembly and membrane localization of the complex, and modulate calcium currents and channel activation/inactivation kinetics. The subunit encoded by this gene undergoes post-translational cleavage to yield the extracellular alpha2 peptide and a membrane-anchored delta polypeptide. This subunit is a receptor for the antiepileptic drug, gabapentin. Mutations in this gene are associated with early infantile epileptic encephalopathy. Single nucleotide polymorphisms in this gene are correlated with increased sensitivity to opioid drugs. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Mar 2014] |
| 生物功能 | The alpha-2/delta subunit of voltage-dependent calcium channels regulates calcium current density and activation/inactivation kinetics of the calcium channel. Acts as a regulatory subunit for P/Q-type calcium channel (CACNA1A), N-type (CACNA1B), L-type (CACNA1C OR CACNA1D) and possibly T-type (CACNA1G). Overexpression induces apoptosis. [UniProt] |
| 细胞定位 | Membrane; Single-pass type I membrane protein. Note=Colocalizes with CACNA1A in lipid raft fractions. [UniProt] |
| 预测分子量 | 130 kDa |
| 翻译后修饰 | May be proteolytically processed into subunits alpha-2-2 and delta-2 that are disulfide-linked. It is however unclear whether such cleavage really takes place in vivo and has a functional role (By similarity). [UniProt] |
检测图片 (1)
ARG59870 anti-CACNA2D2 antibody WB image
Western blot: 25 µg of Rat brain and Mouse brain lysates stained with ARG59870 anti-CACNA2D2 antibody at 1:1000 dilution.
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