anti-CD10 antibody [MEM-78] (FITC)

Key features and details

  • 产品描述: FITC-conjugated Mouse Monoclonal antibody [MEM-78] recognizes CD10
  • 反应物种: Hu
  • 应用: FACS
  • 特异性: The clone MEM-78 reacts with CD10 antigen (CALLA - Common acute lymphatic leukemia antigen), a 100 kDa type II integral membrane protein. HLDA IV; WS Code B 506HLDA V; WS Code B CD10.4
  • 宿主: Mouse
  • 克隆: Monoclonal
  • 克隆号: MEM-78
  • 同位型: IgG1
  • 靶点名称: CD10
  • Brand:
CAT.NO. : ARG62697
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Product Details
概述
产品描述FITC-conjugated Mouse Monoclonal antibody [MEM-78] recognizes CD10
反应物种Hu
应用FACS
特异性The clone MEM-78 reacts with CD10 antigen (CALLA - Common acute lymphatic leukemia antigen), a 100 kDa type II integral membrane protein.
HLDA IV; WS Code B 506
HLDA V; WS Code B CD10.4
宿主Mouse
克隆Monoclonal
克隆号MEM-78
同位型IgG1
靶点名称CD10
抗原物种Human
抗原NALM-6 human pre-B cell line
偶联标记FITC
別名Enkephalinase; Neutral endopeptidase; Neutral endopeptidase 24.11; Common acute lymphocytic leukemia antigen; Neprilysin; CD antigen CD10; CALLA; EC 3.4.24.11; CD10; Skin fibroblast elastase; SFE; Atriopeptidase; NEP
应用说明
应用建议
应用推荐稀释比
FACS20 µl / 10^6 cells
应用说明* The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.
属性
形式Liquid
纯化说明The purified antibody is conjugated with Fluorescein isothiocyanate (FITC) under optimum conditions. The reagent is free of unconjugated FITC and adjusted for direct use. No reconstitution is necessary.
缓冲液PBS, 15 mM Sodium azide and 0.2% (w/v) high-grade protease free BSA
抗菌剂15 mM Sodium azide
稳定剂0.2% (w/v) high-grade protease free BSA
存放说明Aliquot and store in the dark at 2-8°C. Keep protected from prolonged exposure to light. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
注意事项For laboratory research only, not for drug, diagnostic or other use.
生物信息
数据库连接

GeneID: 4311 Human MME

Swiss-port # P08473 Human Neprilysin

基因名称MME
全名membrane metallo-endopeptidase
背景介绍CD10 is a type II transmembrane glycoprotein and a common acute lymphocytic leukemia antigen that is an important cell surface marker in the diagnosis of human acute lymphocytic leukemia (ALL). The encoded protein is present on leukemic cells of pre-B phenotype, which represent 85% of cases of ALL. This protein is not restricted to leukemic cells, however, and is found on a variety of normal tissues. The protein is a neutral endopeptidase that cleaves peptides at the amino side of hydrophobic residues and inactivates several peptide hormones including glucagon, enkephalins, substance P, neurotensin, oxytocin, and bradykinin. [provided by RefSeq, Aug 2017]
生物功能CD10: Thermolysin-like specificity, but is almost confined on acting on polypeptides of up to 30 amino acids (PubMed:15283675, PubMed:8168535). Biologically important in the destruction of opioid peptides such as Met- and Leu-enkephalins by cleavage of a Gly-Phe bond (PubMed:17101991). Able to cleave angiotensin-1, angiotensin-2 and angiotensin 1-9 (PubMed:15283675). Involved in the degradation of atrial natriuretic factor (ANF) (PubMed:2531377, PubMed:2972276). Displays UV-inducible elastase activity toward skin preelastic and elastic fibers (PubMed:20876573). [UniProt]
研究领域Cancer antibody; Developmental Biology antibody; Immune System antibody
预测分子量86 kDa
翻译后修饰Myristoylation is a determinant of membrane targeting.
Glycosylation at Asn-628 is necessary both for surface expression and neutral endopeptidase activity.
检测图片 (1)
  • ARG62697 anti-CD10 antibody [MEM-78] (FITC) FACS image

    Flow Cytometry: Human peripheral blood stained with ARG62697 anti-CD10 antibody [MEM-78] (FITC).

参考文献

克隆号文献

Monoclonal antibodies against human leucocyte antigens. II. Antibodies against CD45 (T200), CD3 (T3), CD43, CD10 (CALLA), transferrin receptor (T9), a novel broadly expressed 18-kDa antigen (MEM-43) and a novel antigen of restricted expression (MEM-74).

Horejsí V et al.
Folia Biol (Praha).,  (1988)

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