anti-CD105 / Endoglin antibody [MEM-229] (PE)
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![anti-CD105 / Endoglin antibody [MEM-229] (PE)](/upload/image/products/ARG53755_FACS_1_201117.jpg)
Key features and details
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- 应用:
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- 靶点名称:
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Product Details
| 产品描述 | PE-conjugated Mouse Monoclonal antibody [MEM-229] recognizes CD105 / Endoglin |
|---|---|
| 反应物种 | Hu, Pig |
| 应用 | FACS |
| 特异性 | The clone MEM-229 recognizes CD105 (Endoglin), a 90 kDa type I integral membrane homodimer glycoprotein expressed on vascular endothelial cells (small and large vessels), activated monocytes and tissue macrophages, stromal cells of certain tissues including bone marrow, pre-B lymphocytes in fetal marrow and erythroid precursors in fetal and adult bone marrow; it is also present on syncytiotrophoblast on placenta throughout pregnancy. |
| 宿主 | Mouse |
| 克隆 | Monoclonal |
| 克隆号 | MEM-229 |
| 同位型 | IgG2a |
| 靶点名称 | CD105 / Endoglin |
| 抗原物种 | Human |
| 抗原 | Recombinant Vaccinia virus containing the human CD105 (L-isoform) cDNA. |
| 偶联标记 | PE |
| 別名 | CD antigen CD105; HHT1; Endoglin; ORW1; END |
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
| 形式 | Liquid |
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| 纯化说明 | The purified antibody is conjugated with R-Phycoerythrin (PE) under optimum conditions. The conjugate is purified by size-exclusion chromatography and adjusted for direct use. No reconstitution is necessary. |
| 缓冲液 | PBS, 15 mM Sodium azide and 0.2% (w/v) high-grade protease free BSA |
| 抗菌剂 | 15 mM Sodium azide |
| 稳定剂 | 0.2% (w/v) high-grade protease free BSA |
| 存放说明 | Aliquot and store in the dark at 2-8°C. Keep protected from prolonged exposure to light. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
| 数据库连接 | |
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| 基因名称 | ENG |
| 全名 | endoglin |
| 背景介绍 | CD105 (Endoglin) is a homodimeric transmembrane glycoprotein serving in presence of TGFbetaR-2 as a receptor for TGFbeta-1 and TGFbeta-3. CD105 is highly expressed on endothelial cells and promotes angiogenesis during wound healing, infarcts and in a wide range of tumours and its gene expression is stimulated by hypoxia. CD105 prevents apoptosis in hypoxic endothelial cells and also antagonises the inhibitory effects of TGFbeta-1 on vascular endothelial cell growth and migration. Normal cellular levels of CD105 are required for formation of new blood vessels. |
| 生物功能 | Major glycoprotein of vascular endothelium. Involved in the regulation of angiogenesis. May play a critical role in the binding of endothelial cells to integrins and/or other RGD receptors. Acts as TGF-beta coreceptor and is involved in the TGF-beta/BMP signaling cascade. Required for GDF2/BMP9 signaling through SMAD1 in endothelial cells and modulates TGF-beta1 signaling through SMAD3. [UniProt] |
| 研究领域 | Cancer antibody; Cell Biology and Cellular Response antibody; Controls and Markers antibody; Developmental Biology antibody; Immune System antibody |
| 预测分子量 | 71 kDa |
ARG53755 anti-CD105 / Endoglin antibody [MEM-229] (PE) FACS image
Flow Cytometry: Separation of HUVEC cells (red-filled) from HEK-293 cells (black-dashed). Cells were stained with ARG53755 anti-CD105 / Endoglin antibody [MEM-229] (PE) (20 µl reagent / 10^6 cells in 100 µl of cell suspension).
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