anti-CD106 / VCAM1 antibody [STA] (APC)
![anti-CD106 / VCAM1 antibody [STA] (APC)](/upload/image/products/ARG53756_FACS_1_210_205.jpg)
![anti-CD106 / VCAM1 antibody [STA] (APC)](/upload/image/products/ARG53756_FACS_1.jpg)
Key features and details
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- 靶点名称:
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CAT.NO. : ARG53756
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Product Details
概述
| 产品描述 | APC-conjugated Mouse Monoclonal antibody [STA] recognizes CD106 / VCAM1 |
|---|---|
| 反应物种 | Hu |
| 应用 | FACS |
| 特异性 | The clone STA recognizes CD106 antigen (VCAM-1), a 100-110 kDa type I membrane protein of the immunoglobulin superfamily, a crucial mediator of leukocyte adhesion, and a costimulation molecule. HLDA V; WS Code A013 |
| 宿主 | Mouse |
| 克隆 | Monoclonal |
| 克隆号 | STA |
| 同位型 | IgG1 |
| 靶点名称 | CD106 / VCAM1 |
| 抗原物种 | Human |
| 抗原 | Human DS6 T cell line |
| 偶联标记 | APC |
| 別名 | CD106; INCAM-100; Vascular cell adhesion protein 1; VCAM-1; CD antigen CD106; V-CAM 1 |
应用说明
| 应用建议 |
| ||||
|---|---|---|---|---|---|
| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 纯化说明 | The purified antibody is conjugated with cross-linked Allophycocyanin (APC) under optimum conditions. The conjugate is purified by size-exclusion chromatography and adjusted for direct use. No reconstitution is necessary. |
| 缓冲液 | PBS, 15 mM Sodium azide and 0.2% (w/v) high-grade protease free BSA |
| 抗菌剂 | 15 mM Sodium azide |
| 稳定剂 | 0.2% (w/v) high-grade protease free BSA |
| 存放说明 | Aliquot and store in the dark at 2-8°C. Keep protected from prolonged exposure to light. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | VCAM1 |
| 全名 | vascular cell adhesion molecule 1 |
| 背景介绍 | CD106 / VCAM-1 (vascular cell adhesion molecule-1) is an Ig-like cell surface adhesion molecule binding VLA-4 integrin. VCAM-1 is a potent T cell costimulatory molecule taking part in their positive selection and survival, as well as in adhesion, transendothelial migration and activation of peripheral T cells. VCAM-1 is also involved in endothelial cell-cell contacts. Whereas VCAM-1 normally mediates leukocyte extravasion to sites of tissue inflammation, tumour cells can use overexpressed VCAM-1 to escape T cell immunity. Soluble form of VCAM-1 (sVCAM-1) is an inflammatory marker and can be used also in prognosis of subsequent cariovascular events following acute coronary syndromes. |
| 生物功能 | Important in cell-cell recognition. Appears to function in leukocyte-endothelial cell adhesion. Interacts with integrin alpha-4/beta-1 (ITGA4/ITGB1) on leukocytes, and mediates both adhesion and signal transduction. The VCAM1/ITGA4/ITGB1 interaction may play a pathophysiologic role both in immune responses and in leukocyte emigration to sites of inflammation. [UniProt] |
| 研究领域 | Cancer antibody; Cell Biology and Cellular Response antibody; Developmental Biology antibody; Neuroscience antibody; Signaling Transduction antibody |
| 预测分子量 | 81 kDa |
| 翻译后修饰 | Sialoglycoprotein. |
检测图片 (1)
ARG53756 anti-CD106 / VCAM1 antibody [STA] (APC) FACS image
Flow Cytometry: HDLM-2 cells (red) and Granulocytes (black-dashed, negative control) stained with ARG53756 anti-CD106 / VCAM1 antibody [STA] (APC).
参考文献
克隆号文献
Modeling the early events of severe acute respiratory syndrome coronavirus infection in vitro.
Expression of VCAM-1 (CD106) by a subset of TCR gamma delta-bearing lymphocyte clones. Involvement of a metalloprotease in the specific hydrolytic release of the soluble isoform.
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