anti-CD107b / LAMP2 antibody [H4B4] (APC)
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![anti-CD107b / LAMP2 antibody [H4B4] (APC)](/upload/image/products/ARG54252_FACS_1.jpg)
Key features and details
- 产品描述:
- 反应物种:
- 不反应物种:
- 应用:
- 特异性:
- 宿主:
- 克隆:
- 克隆号:
- 同位型:
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Brand:
Product Details
| 产品描述 | APC-conjugated Mouse Monoclonal antibody [H4B4] recognizes CD107b / LAMP2 |
|---|---|
| 反应物种 | Hu |
| 不反应物种 | Ms, Rat |
| 应用 | FACS |
| 特异性 | The mouse monoclonal antibody H4B4 recognizes CD107b / LAMP2, an extensively glycosylated 100120 kDa widely expressed lysosomeassociated protein. HLDA V.; WS Code P007 |
| 宿主 | Mouse |
| 克隆 | Monoclonal |
| 克隆号 | H4B4 |
| 同位型 | IgG1 |
| 靶点名称 | CD107b / LAMP2 |
| 抗原物种 | Human |
| 抗原 | Human PBMC |
| 偶联标记 | APC |
| 別名 | CD antigen CD107b; LAMPB; CD107b; LGP110; Lysosome-associated membrane glycoprotein 2; LAMP-2; CD107 antigen-like family member B; Lysosome-associated membrane protein 2 |
| 应用建议 |
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|---|---|---|---|---|---|
| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
| 形式 | Liquid |
|---|---|
| 纯化说明 | The purified antibody is conjugated with cross-linked Allophycocyanin (APC) under optimum conditions. The conjugate is purified by size-exclusion chromatography and adjusted for direct use. No reconstitution is necessary. |
| 缓冲液 | PBS, 0.02% Sodium azide and 0.2% (w/v) high-grade protease free BSA |
| 抗菌剂 | 0.02% Sodium azide |
| 稳定剂 | 0.2% (w/v) high-grade protease free BSA |
| 存放说明 | Aliquot and store in the dark at 2-8°C. Keep protected from prolonged exposure to light. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
| 数据库连接 | Swiss-port # P13473 Human Lysosome-associated membrane glycoprotein 2 |
|---|---|
| 基因名称 | LAMP2 |
| 全名 | lysosomal-associated membrane protein 2 |
| 背景介绍 | CD107b (lysosome-associated membrane protein-2, LAMP-2), together with CD107a / LAMP-1, is a major constituent of lysosomal membrane. The LAMP proteins are involved in lysosome biogenesis and are required for fusion of lysosomes with phagosomes,especially CD107b is important regulator in successful phagosomal maturation. CD107b deficiency causes an accumulation of autophagosomes in many tissues leading to cardiomyopathy and myopathy (Danons disease). Immature CD107b is an approximately 45 kDa protein, but after extensive glycosylation the mature glycoprotein has about 100-120 kDa. |
| 生物功能 | Implicated in tumor cell metastasis. May function in protection of the lysosomal membrane from autodigestion, maintenance of the acidic environment of the lysosome, adhesion when expressed on the cell surface (plasma membrane), and inter- and intracellular signal transduction. Protects cells from the toxic effects of methylating mutagens. [UniProt] |
| 研究领域 | Cell Biology and Cellular Response antibody; Cell Death antibody; Controls and Markers antibody; Developmental Biology antibody; Immune System antibody; Metabolism antibody; Signaling Transduction antibody |
| 预测分子量 | 45 kDa |
| 翻译后修饰 | O- and N-glycosylated; some of the 16 N-linked glycans are polylactosaminoglycans. |
ARG54252 anti-CD107b / LAMP2 antibody [H4B4] (APC) FACS image
Flow Cytometry: IgE-stimulated Human peripheral blood stained with ARG54252 anti-CD107b / LAMP2 antibody [H4B4] (APC).
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