anti-CD138 / Syndecan 1 antibody [B-A38] (azide free)

产品描述: Azide free Mouse Monoclonal antibody [B-A38] recognizes CD138 / Syndecan 1
反应物种: Hu, Ms
预测物种: Gpig, Rat
应用: FACS, ICC/IF, IHC-Fr, IHC-P
特异性: The antibody BA38 recognizes CD138 (syndecan 1), a heparan sulfate proteoglycan protein expressed mainly in the epidermis and plasma cells, but also in growth factorstimulated lymphocytes. The MWs of the glycosylated CD138 were variety, and MW of the non-glycosylated core protein (dimmer form) was around 60-80 kda.
宿主: Mouse
克隆: Monoclonal
克隆号: B-A38
同位型: IgG1

CAT.NO. : ARG65410

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Size:

50 μg

Product Details

概述

产品描述	Azide free Mouse Monoclonal antibody [B-A38] recognizes CD138 / Syndecan 1
反应物种	Hu, Ms
预测物种	Gpig, Rat
应用	FACS, ICC/IF, IHC-Fr, IHC-P
特异性	The antibody BA38 recognizes CD138 (syndecan 1), a heparan sulfate proteoglycan protein expressed mainly in the epidermis and plasma cells, but also in growth factorstimulated lymphocytes. The MWs of the glycosylated CD138 were variety, and MW of the non-glycosylated core protein (dimmer form) was around 60-80 kda.
宿主	Mouse
克隆	Monoclonal
克隆号	B-A38
同位型	IgG1
靶点名称	CD138 / Syndecan 1
抗原物种	Human
抗原	U266 human peripheral blood myeloma cell line
偶联标记	Un-conjugated
別名	CD antigen CD138; syndecan; CD138; SDC; Syndecan-1; SYND1

应用说明

应用建议

应用说明

* The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.

属性

形式	Liquid
纯化	Purification with Protein A.
纯化说明	0.2 µm filter sterilized.
纯度	> 95% (by SDS-PAGE)
缓冲液	PBS (pH 7.4)
浓度	1 mg/ml
存放说明	For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
注意事项	For laboratory research only, not for drug, diagnostic or other use.

生物信息

数据库连接	GeneID: 20969 Mouse SDC1 GeneID: 6382 Human SDC1 Swiss-port # P18827 Human Syndecan-1 Swiss-port # P18828 Mouse Syndecan-1
基因名称	SDC1
全名	syndecan 1
背景介绍	CD138 (syndecan 1) is a transmembrane proteoglycan that can bind a variety of cytokines and modulate their activity, as well as the activity of extracellular matrix components and influence many developmental processes. CD138 is expressed mainly in differentiating keratinocytes and is transiently upregulated in all layers of the epidermis upon tissue injury. It is also highly expressed on plasma cells and can be detected even on fibroblasts, vascular smooth muscle cells and endothelial cells. Up-regulation and down-regulation of CD138 on the cell surface often correlates with the gain of cancerous characteristics. Serum levels of the shedded soluble sCD138 are used as a prognostic factor of cancerogenesis.
生物功能	Cell surface proteoglycan that bears both heparan sulfate and chondroitin sulfate and that links the cytoskeleton to the interstitial matrix. [UniProt]
研究领域	Cancer antibody; Developmental Biology antibody; Metabolism antibody; Neuroscience antibody; Signaling Transduction antibody
预测分子量	32 kDa
翻译后修饰	Shedding is enhanced by a number of factors such as heparanase, thrombin or EGF. Also by stress and wound healing. PMA-mediated shedding is inhibited by TIMP3.

检测图片 (1)

ARG65410 anti-CD138 / Syndecan 1 antibody [B-A38] (azide free) FACS image
Flow Cytometry: Human peripheral blood stained with ARG65410 anti-CD138 / Syndecan 1 antibody [B-A38] (azide free), followed by incubation with APC labelled Goat anti-Mouse secondary antibody.

参考文献

Cell surface-expressed Ro52/IgG/HLA-DR complex is targeted by autoantibodies in patients with inflammatory myopathies

IHC-P / Human

Noriko Arase et al.
J Autoimmun., (2022)