anti-CD169 / Siglec 1 antibody [7-239] (APC)

产品描述: APC-conjugated Mouse Monoclonal antibody [7-239] recognizes CD169 / Siglec 1
反应物种: Hu
应用: FACS
特异性: The mouse monoclonal antibody 7-239 recognizes an extracellular epitope of CD169 (sialoadhesin, Siglec-1), a 210 kDa type I transmembrane glycoprotein expressed on macrophages and dendritic cells.
宿主: Mouse
克隆: Monoclonal
克隆号: 7-239
同位型: IgG1
靶点名称: CD169 / Siglec 1

CAT.NO. : ARG42302

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Size:

50 tests

Product Details

概述

产品描述	APC-conjugated Mouse Monoclonal antibody [7-239] recognizes CD169 / Siglec 1
反应物种	Hu
应用	FACS
特异性	The mouse monoclonal antibody 7-239 recognizes an extracellular epitope of CD169 (sialoadhesin, Siglec-1), a 210 kDa type I transmembrane glycoprotein expressed on macrophages and dendritic cells.
宿主	Mouse
克隆	Monoclonal
克隆号	7-239
同位型	IgG1
靶点名称	CD169 / Siglec 1
抗原物种	Human
抗原	Human rhinovirus 14-infected monocyte-derived dendritic cells.
偶联标记	APC
別名	CD169; Siglec-1; dJ1009E24.1; Sialic acid-binding Ig-like lectin 1; SIGLEC-1; CD antigen CD169; SN; Sialoadhesin

应用说明

应用建议

应用	推荐稀释比
FACS	10 µl / 100 µl of whole blood or 10^6 cells

应用说明

* The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.

属性

形式	Liquid
纯化	Purified
缓冲液	PBS and 15 mM Sodium azide.
抗菌剂	15 mM Sodium azide
存放说明	Aliquot and store in the dark at 2-8°C. Keep protected from prolonged exposure to light. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
注意事项	For laboratory research only, not for drug, diagnostic or other use.

生物信息

数据库连接	GeneID: 6614 Human SIGLEC1 Swiss-port # Q9BZZ2 Human Sialoadhesin
基因名称	SIGLEC1
全名	sialic acid binding Ig-like lectin 1, sialoadhesin
背景介绍	This gene encodes a member of the immunoglobulin superfamily. The encoded protein is a lectin-like adhesion molecule that binds glycoconjugate ligands on cell surfaces in a sialic acid-dependent manner. It is a type I transmembrane protein expressed only by a subpopulation of macrophages and is involved in mediating cell-cell interactions. Alternative splicing produces a transcript variant encoding an isoform that is soluble rather than membrane-bound; however, the full-length nature of this variant has not been determined. [provided by RefSeq, Jul 2008]
生物功能	Acts as an endocytic receptor mediating clathrin dependent endocytosis. Macrophage-restricted adhesion molecule that mediates sialic-acid dependent binding to lymphocytes, including granulocytes, monocytes, natural killer cells, B-cells and CD8 T-cells. Preferentially binds to alpha-2,3-linked sialic acid (By similarity). Binds to SPN/CD43 on T-cells (By similarity). May play a role in hemopoiesis. [UniProt]
细胞定位	Isoform 1: Cell membrane; Single-pass type I membrane protein. Isoform 2: Secreted. [UniProt]
预测分子量	183 kDa

检测图片 (3)

ARG42302 anti-CD169 / Siglec 1 antibody [7-239] (APC) FACS image
Flow Cytometry: Human TNF alpha and INF gamma stimulated peripheral blood mononuclear cells stained with ARG42302 anti-CD169 / Siglec 1 antibody [7-239] (APC) at 10 µl / 10^6 cells in 100 µl of cell suspension.
ARG42302 anti-CD169 / Siglec 1 antibody [7-239] (APC) FACS image
Flow Cytometry: Human TNF alpha and INF gamma stimulated peripheral blood mononuclear cells stained with ARG42302 anti-CD169 / Siglec 1 antibody [7-239] (APC) at 10 µl / 10^6 cells in 100 µl of cell suspension and ARG62720 anti-CD11c antibody [BU15] (FITC) at 20 µl / 100 µl of peripheral whole blood.
ARG42302 anti-CD169 / Siglec 1 antibody [7-239] (APC) FACS image
Flow Cytometry: Separation of Human CD169 positive CD11c positive cells (red-filled) from CD169 negative CD11c negative cells (black-dashed). Human TNF alpha and INF gamma stimulated peripheral blood mononuclear cells stained with ARG42302 anti-CD169 / Siglec 1 antibody [7-239] (APC) at 10 µl / 10^6 cells in 100 µl of cell suspension.

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