anti-CD177 antibody [MEM-166] (FITC)
CAT.NO. : ARG62749
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概述
产品描述 | FITC-conjugated Mouse Monoclonal antibody [MEM-166] recognizes CD177 |
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反应物种 | Hu, NHuPrm |
应用 | FACS |
特异性 | The clone MEM-166 reacts with CD177 (Neutrophil specific antigen 1), a 60 kDa GPI-linked cell surface glycoprotein of uPAR family, expressed on granulocytes and in bone marrow early erythroblasts, megakaryocytes, promyelocytes and myelocytes. HLDA VI; WS Code M M17 HLDA VI; WS Code BP 309 |
宿主 | Mouse |
克隆 | Monoclonal |
克隆号 | MEM-166 |
同位型 | IgG1 |
靶点名称 | CD177 |
抗原物种 | Human |
抗原 | Human granulocytes |
偶联标记 | FITC |
別名 | NB1 glycoprotein; PRV-1; PRV1; NB1; CD177 antigen; Human neutrophil alloantigen 2a; NB1 GP; HNA2A; Polycythemia rubra vera protein 1; CD antigen CD177; HNA-2a |
应用说明
应用建议 |
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应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
形式 | Liquid |
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纯化说明 | The purified antibody is conjugated with Fluorescein isothiocyanate (FITC) under optimum conditions. The reagent is free of unconjugated FITC and adjusted for direct use. No reconstitution is necessary. |
缓冲液 | PBS, 15 mM Sodium azide and 0.2% (w/v) high-grade protease free BSA |
抗菌剂 | 15 mM Sodium azide |
稳定剂 | 0.2% (w/v) high-grade protease free BSA |
存放说明 | Aliquot and store in the dark at 2-8°C. Keep protected from prolonged exposure to light. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
数据库连接 | |
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基因名称 | CD177 |
全名 | CD177 molecule |
背景介绍 | CD177 (NB1/HNA-2a and PRV-1 form) is a GPI-anchored glycoprotein present mainly on neutrophils. Its plasma membrane expression is increased during pregnancy and and inflammation or after G-CSF application. Ligand of CD177 has been identified as CD31 (PECAM-1). CD177 participates in neutrophil transmigration and seems to be also a pro-proliferative molecule. The antibodies against CD177 can be involved in neonatal alloimmune neutropenia (NAN). |
研究领域 | Immune System antibody |
预测分子量 | 46 kDa |
翻译后修饰 | N-glycosylated. A soluble form may also be produced by proteolytic cleavage at the cell surface (shedding). |
检测图片 (2)
ARG62749 anti-CD177 antibody [MEM-166] (FITC) FACS image
Flow Cytometry: Human peripheral whole blood stained with ARG62749 anti-CD177 antibody [MEM-166] (FITC) (20 µl reagent / 100 µl of peripheral whole blood).
ARG62749 anti-CD177 antibody [MEM-166] (FITC) FACS image
Flow Cytometry: Separation of human CD177 positive neutrophil granulocytes (red-filled) from lymphocytes (black-dashed). Human peripheral whole blood stained with ARG62749 anti-CD177 antibody [MEM-166] (FITC) (20 µl reagent / 100 µl of peripheral whole blood).
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