anti-CD192 / CCR2 antibody

Key features and details

  • 产品描述: Rabbit Polyclonal antibody recognizes CD192 / CCR2
  • 反应物种: Hu, Ms
  • 应用: FACS, IHC-P
  • 宿主: Rabbit
  • 克隆: Polyclonal
  • 同位型: IgG
  • 靶点名称: CD192 / CCR2
  • 抗原物种: Human
  • 抗原: Synthetic peptide derived from Human CD192 / CCR2.
  • Brand:
CAT.NO. : ARG59880
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Product Details
概述
产品描述Rabbit Polyclonal antibody recognizes CD192 / CCR2
反应物种Hu, Ms
应用FACS, IHC-P
宿主Rabbit
克隆Polyclonal
同位型IgG
靶点名称CD192 / CCR2
抗原物种Human
抗原Synthetic peptide derived from Human CD192 / CCR2.
偶联标记Un-conjugated
別名CCR2B; CD192; CKR2; Monocyte chemoattractant protein 1 receptor; CCR-2; CKR2B; CKR2A; CMKBR2; CCR2; C-C CKR-2; CC-CKR-2; CD antigen CD192; MCP-1-R; CCR2A; C-C chemokine receptor type 2
应用说明
应用建议
应用推荐稀释比
FACS1:100
IHC-P1:50 - 1:200
应用说明* The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.
属性
形式Liquid
纯化Affinity purified.
缓冲液PBS (pH 7.4), 0.02% Sodium azide and 50% Glycerol.
抗菌剂0.02% Sodium azide
稳定剂50% Glycerol
存放说明For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
注意事项For laboratory research only, not for drug, diagnostic or other use.
生物信息
数据库连接

GeneID: 12772 Mouse CCR2

GeneID: 729230 Human CCR2

Swiss-port # P41597 Human C-C chemokine receptor type 2

Swiss-port # P51683 Mouse C-C chemokine receptor type 2

基因名称CCR2
全名chemokine (C-C motif) receptor 2
背景介绍This gene encodes two isoforms of a receptor for monocyte chemoattractant protein-1, a chemokine which specifically mediates monocyte chemotaxis. Monocyte chemoattractant protein-1 is involved in monocyte infiltration in inflammatory diseases such as rheumatoid arthritis as well as in the inflammatory response against tumors. The receptors encoded by this gene mediate agonist-dependent calcium mobilization and inhibition of adenylyl cyclase. This gene is located in the chemokine receptor gene cluster region. Two alternatively spliced transcript variants are expressed by the gene. [provided by RefSeq, Mar 2009]
生物功能Receptor for the CCL2, CCL7 and CCL13 chemokines. Transduces a signal by increasing intracellular calcium ion levels. Alternative coreceptor with CD4 for HIV-1 infection. [UniProt]
细胞定位Cell membrane; Multi-pass membrane protein. Note=The chemoattractant receptors are distributed throughout the cell surface; after stimulation with a ligand, such as CCL2, they are rapidly recruited into microdomain clusters at the cell membrane. [UniProt]
预测分子量42 kDa
翻译后修饰N-glycosylated.

Sulfation increases the affinity for both monomeric and dimeric CCL2 with stronger binding to the monomeric form. Binding of sulfated CCR2 to CCL2 promotes conversion of CCL2 from dimer to monomer. [UniProt]
检测图片 (1)
  • ARG59880 anti-CD192 / CCR2 antibody IHC-P image

    Immunohistochemistry: Paraffin-embedded Human tonsil stained with ARG59880 anti-CD192 / CCR2 antibody.

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