anti-CD253 / TRAIL antibody [B-S23] (low endotoxin)
![anti-CD253 / TRAIL antibody [B-S23] (low endotoxin)](/upload/image/20241105/8415bc38bc270b898ee2a90369a6c7fb.jpg)
Key features and details
- 产品描述:
- 反应物种:
- 应用:
- 特异性:
- 宿主:
- 克隆:
- 克隆号:
- 同位型:
- 靶点名称:
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Brand:
CAT.NO. : ARG23335
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Product Details
概述
| 产品描述 | Azide free and low endotoxin Mouse Monoclonal antibody [B-S23] recognizes CD253 / TRAIL |
|---|---|
| 反应物种 | Hu |
| 应用 | ELISA, FACS, FuncSt |
| 特异性 | This antibody recognizes the TRAIL, APO2L antigen, a 32 kDa protein. Clone B-S23 induced apoptosis in U937 cells. |
| 宿主 | Mouse |
| 克隆 | Monoclonal |
| 克隆号 | B-S23 |
| 同位型 | IgG1 |
| 靶点名称 | CD253 / TRAIL |
| 抗原物种 | Human |
| 抗原 | Recombinant human TRAIL |
| 偶联标记 | Un-conjugated |
| 別名 | TL2; CD253; Protein TRAIL; TNF-related apoptosis-inducing ligand; TRAIL; CD antigen CD253; Apo-2 ligand; Apo-2L; APO2L; Tumor necrosis factor ligand superfamily member 10 |
应用说明
| 应用建议 |
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|---|---|---|---|---|---|---|---|---|---|
| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 纯化说明 | Sterile-filtered through 0.22 µm and treated to remove endotoxins. |
| 缓冲液 | PBS |
| 浓度 | 2.3 mg/ml |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | Swiss-port # P50591 Human Tumor necrosis factor ligand superfamily member 10 |
|---|---|
| 基因名称 | TNFSF10 |
| 全名 | tumor necrosis factor (ligand) superfamily, member 10 |
| 背景介绍 | The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This protein preferentially induces apoptosis in transformed and tumor cells, but does not appear to kill normal cells although it is expressed at a significant level in most normal tissues. This protein binds to several members of TNF receptor superfamily including TNFRSF10A/TRAILR1, TNFRSF10B/TRAILR2, TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4, and possibly also to TNFRSF11B/OPG. The activity of this protein may be modulated by binding to the decoy receptors TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4, and TNFRSF11B/OPG that cannot induce apoptosis. The binding of this protein to its receptors has been shown to trigger the activation of MAPK8/JNK, caspase 8, and caspase 3. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2010] |
| 生物功能 | Cytokine that binds to TNFRSF10A/TRAILR1, TNFRSF10B/TRAILR2, TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4 and possibly also to TNFRSF11B/OPG. Induces apoptosis. Its activity may be modulated by binding to the decoy receptors TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4 and TNFRSF11B/OPG that cannot induce apoptosis. [UniProt] |
| 预测分子量 | 33 kDa |
| 翻译后修饰 | Tyrosine phosphorylated by PKDCC/VLK. [UniProt] |
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