anti-CD4 antibody [GK1.5] (APC)
![anti-CD4 antibody [GK1.5] (APC)](/upload/image/products/ARG53843_FACS_1_210_205.jpg)
![anti-CD4 antibody [GK1.5] (APC)](/upload/image/products/ARG53843_FACS_1.jpg)
Key features and details
- 产品描述:
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- 特异性:
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- 靶点名称:
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CAT.NO. : ARG53843
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Product Details
概述
| 产品描述 | APC-conjugated Rat Monoclonal antibody [GK1.5] recognizes CD4 |
|---|---|
| 反应物种 | Ms |
| 应用 | FACS |
| 特异性 | The clone GK1.5 reacts with an extracellular epitope of mouse CD4 transmembrane glycoprotein (55 kDa). |
| 宿主 | Rat |
| 克隆 | Monoclonal |
| 克隆号 | GK1.5 |
| 同位型 | IgG2b, kappa |
| 靶点名称 | CD4 |
| 抗原物种 | Mouse |
| 抗原 | Mouse CTL clone V4 cells |
| 抗原表位 | extracellular epitope of mouse CD4 |
| 偶联标记 | APC |
| 別名 | CD4mut; CD antigen CD4; T-cell surface glycoprotein CD4; T-cell surface antigen T4/Leu-3 |
应用说明
| 应用建议 |
| ||||
|---|---|---|---|---|---|
| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 纯化说明 | The purified antibody is conjugated with cross-linked Allophycocyanin (APC) under optimum conditions. The conjugate is purified by size-exclusion chromatography. |
| 缓冲液 | PBS (pH 7.4) and 15 mM Sodium azide |
| 抗菌剂 | 15 mM Sodium azide |
| 浓度 | 0.5 mg/ml |
| 存放说明 | Aliquot and store in the dark at 2-8°C. Keep protected from prolonged exposure to light. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | CD4 |
| 全名 | CD4 molecule |
| 背景介绍 | CD4 is a membrane glycoprotein of T lymphocytes that interacts with major histocompatibility complex class II antigenes and is also a receptor for the human immunodeficiency virus. This gene is expressed not only in T lymphocytes, but also in B cells, macrophages, and granulocytes. It is also expressed in specific regions of the brain. The protein functions to initiate or augment the early phase of T-cell activation, and may function as an important mediator of indirect neuronal damage in infectious and immune-mediated diseases of the central nervous system. Multiple alternatively spliced transcript variants encoding different isoforms have been identified in this gene. [provided by RefSeq, Aug 2010] |
| 生物功能 | CD4 is an integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kinase LCK to the vicinity of the TCR-CD3 complex. LCK then initiates different intracellular signaling pathways by phosphorylating various substrates ultimately leading to lymphokine production, motility, adhesion and activation of T-helper cells. In other cells such as macrophages or NK cells, plays a role in differentiation/activation, cytokine expression and cell migration in a TCR/LCK-independent pathway. Participates in the development of T-helper cells in the thymus and triggers the differentiation of monocytes into functional mature macrophages. [UniProt] |
| 产品亮点 | Related products: CD4 antibodies; CD4 ELISA Kits; CD4 Duos / Panels; Anti-Rat IgG secondary antibodies; Related news: New antibody panels and duos for Tumor immune microenvironment Tumor-Infiltrating Lymphocytes (TILs) |
| 研究领域 | Developmental Biology antibody; Immune System antibody; Regulatory T cells Study antibody; T-cell infiltration Study antibody; Tumor-infiltrating Lymphocyte Study antibody |
| 预测分子量 | 51 kDa |
| 翻译后修饰 | Palmitoylation and association with LCK contribute to the enrichment of CD4 in lipid rafts. |
检测图片 (1)
ARG53843 anti-CD4 antibody [GK1.5] (APC) FACS image
Flow Cytometry: Mouse splenocytes stained with ARG53843 anti-CD4 antibody [GK1.5] (APC).
参考文献
克隆号文献
Myxoma virus expressing a fusion protein of interleukin-15 (IL15) and IL15 receptor alpha has enhanced antitumor activity.
IHC-Fr / Mouse
Autologous tumor vaccine modified with recombinant new castle disease virus expressing IL-7 promotes antitumor immune response.
Supplementation of influenza split vaccines with conserved M2 ectodomains overcomes strain specificity and provides long-term cross protection.
Enhancement of systemic tumor immunity for squamous cell carcinoma cells by an oncolytic herpes simplex virus.
IHC-Fr / Mouse
A quantitative study of the mechanisms behind thymic atrophy in Gαi2-deficient mice during colitis development.
FACS / Mouse
Abdominal γ-radiation induces an accumulation of function-impaired regulatory T cells in the small intestine.
IHC-Fr / Mouse
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