anti-CD41 antibody [MEM-06] (FITC)

产品描述: FITC-conjugated Mouse Monoclonal antibody [MEM-06] recognizes CD41
反应物种: Hu
应用: FACS
特异性: The clone MEM-06 reacts with CD41 (GPIIb), a transmembrane glycoprotein (integrin family) composed of two chains GPIIb alpha (heavy chain; 120 kDa) and GPIIb beta (light chain; 23 kDa). CD41 is mainly expressed on platelets and megakaryocytes.
宿主: Mouse
克隆: Monoclonal
克隆号: MEM-06
同位型: IgG1
靶点名称: CD41

CAT.NO. : ARG62842

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Size:

100 tests

Product Details

概述

产品描述	FITC-conjugated Mouse Monoclonal antibody [MEM-06] recognizes CD41
反应物种	Hu
应用	FACS
特异性	The clone MEM-06 reacts with CD41 (GPIIb), a transmembrane glycoprotein (integrin family) composed of two chains GPIIb alpha (heavy chain; 120 kDa) and GPIIb beta (light chain; 23 kDa). CD41 is mainly expressed on platelets and megakaryocytes.
宿主	Mouse
克隆	Monoclonal
克隆号	MEM-06
同位型	IgG1
靶点名称	CD41
抗原	Leukocytes of patient suffering from LGL-type leukaemia.
偶联标记	FITC
別名	GTA; GT; GPalpha IIb; PPP1R93; CD41; BDPLT2; BDPLT16; GP2B; Integrin alpha-IIb; GPIIb; Platelet membrane glycoprotein IIb; HPA3; CD antigen CD41; CD41B

应用说明

应用建议

应用	推荐稀释比
FACS	20 µl / 10^6 cells

应用说明

* The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.

属性

形式	Liquid
纯化说明	The purified antibody is conjugated with Fluorescein isothiocyanate (FITC) under optimum conditions. The reagent is free of unconjugated FITC and adjusted for direct use. No reconstitution is necessary.
缓冲液	PBS, 15 mM Sodium azide and 0.2% (w/v) high-grade protease free BSA
抗菌剂	15 mM Sodium azide
稳定剂	0.2% (w/v) high-grade protease free BSA
存放说明	Aliquot and store in the dark at 2-8°C. Keep protected from prolonged exposure to light. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
注意事项	For laboratory research only, not for drug, diagnostic or other use.

生物信息

数据库连接	GeneID: 3674 Human ITGA2B Swiss-port # P08514 Human Integrin alpha-IIb
基因名称	ITGA2B
全名	integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41)
背景介绍	CD41 (platelet glycoprotein IIb) is composed of two subunits (120 kDa a, alpha and 23 kDa b, beta) that interact with CD61 in the presence of calcium to form a functional adhesive protein receptor. Upon blood vessel damage, this receptor binds to a variety of proteins including von Willebrand factor, fibrinogen, fibronectin and vitronectin. CD41 is mainly expressed on megakaryocyte-platelet lineage, but generally belongs to the antigens that are expressed during early stages of hematopoietic differentiation.
生物功能	Integrin alpha-IIb/beta-3 is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. It recognizes the sequence R-G-D in a wide array of ligands. It recognizes the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain. Following activation integrin alpha-IIb/beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen. This step leads to rapid platelet aggregation which physically plugs ruptured endothelial cell surface. [UniProt]
研究领域	Cell Biology and Cellular Response antibody; Developmental Biology antibody; Immune System antibody; Signaling Transduction antibody
预测分子量	113 kDa

检测图片 (2)

ARG62842 anti-CD41 antibody [MEM-06] (FITC) FACS image
Flow Cytometry: Human peripheral whole blood stained with ARG62842 anti-CD41 antibody [MEM-06] (FITC) (20 µl reagent / 100 µl of peripheral whole blood).
ARG62842 anti-CD41 antibody [MEM-06] (FITC) FACS image
Flow Cytometry: Separation of human CD41 positive thrombocytes (red-filled) from CD41 negative lymphocytes (black-dashed). Human peripheral whole blood stained with ARG62842 anti-CD41 antibody [MEM-06] (FITC) (20 µl reagent / 100 µl of peripheral whole blood).