anti-CD45RA antibody [MEM-56] (Biotin)
![anti-CD45RA antibody [MEM-56] (Biotin)](/upload/image/products/ARG62862_FACS_1_210_205.jpg)
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CAT.NO. : ARG62862
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Product Details
概述
| 产品描述 | Biotin-conjugated Mouse Monoclonal antibody [MEM-56] recognizes CD45RA |
|---|---|
| 反应物种 | Hu |
| 应用 | FACS |
| 特异性 | The clone MEM-56 reacts with CD45RA, a 205-220 kDa single chain type I glycoprotein, variant of CD45 (CD45RA isoform). CD45RA is expressed on most of B lymphocytes, resting and native T lymphocytes, medullar thymocytes and monocytes. HLDA IV; WS Code NL 907 |
| 宿主 | Mouse |
| 克隆 | Monoclonal |
| 克隆号 | MEM-56 |
| 同位型 | IgG2b |
| 靶点名称 | CD45RA |
| 抗原物种 | Human |
| 抗原 | Human thymocytes and T lymphocytes. |
| 偶联标记 | Biotin |
| 別名 | LY5; GP180; Receptor-type tyrosine-protein phosphatase C; CD45; L-CA; CD antigen CD45; Leukocyte common antigen; CD45R; LCA; T200; EC 3.1.3.48; B220 |
应用说明
| 应用建议 |
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|---|---|---|---|---|---|
| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 纯化说明 | The purified antibody is conjugated with Biotin-LC-NHS under optimum conditions. The reagent is free of unconjugated biotin. |
| 缓冲液 | TBS (pH 8.0) and 15 mM Sodium azide |
| 抗菌剂 | 15 mM Sodium azide |
| 浓度 | 1 mg/ml |
| 存放说明 | Aliquot and store in the dark at 2-8°C. Keep protected from prolonged exposure to light. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | Swiss-port # P08575 Human Receptor-type tyrosine-protein phosphatase C |
|---|---|
| 基因名称 | PTPRC |
| 全名 | protein tyrosine phosphatase, receptor type, C |
| 背景介绍 | CD45 is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitosis, and oncogenic transformation. This PTP contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus is classified as a receptor type PTP. This PTP has been shown to be an essential regulator of T- and B-cell antigen receptor signaling. It functions through either direct interaction with components of the antigen receptor complexes, or by activating various Src family kinases required for the antigen receptor signaling. This PTP also suppresses JAK kinases, and thus functions as a regulator of cytokine receptor signaling. Alternatively spliced transcripts variants of this gene, which encode distinct isoforms, have been reported. [provided by RefSeq, Jun 2012] |
| 生物功能 | CD45: Protein tyrosine-protein phosphatase required for T-cell activation through the antigen receptor. Acts as a positive regulator of T-cell coactivation upon binding to DPP4. The first PTPase domain has enzymatic activity, while the second one seems to affect the substrate specificity of the first one. Upon T-cell activation, recruits and dephosphorylates SKAP1 and FYN. Dephosphorylates LYN, and thereby modulates LYN activity. (Microbial infection) Acts as a receptor for human cytomegalovirus protein UL11 and mediates binding of UL11 to T-cells, leading to reduced induction of tyrosine phosphorylation of multiple signaling proteins upon T-cell receptor stimulation and impaired T-cell proliferation. [UniProt] |
| 研究领域 | Developmental Biology antibody; Immune System antibody; Neuroscience antibody; Signaling Transduction antibody; Mouse Inflammatory Cell Marker antibody;B Cell Marker antibody |
| 预测分子量 | 147 kDa |
| 翻译后修饰 | Heavily N- and O-glycosylated. |
检测图片 (1)
ARG62862 anti-CD45RA antibody [MEM-56] (Biotin) FACS image
Flow Cytometry: Human peripheral blood stained with ARG62862 anti-CD45RA antibody [MEM-56] (Biotin), followed by Streptavidin (APC).
参考文献
克隆号文献
Origins of tumor-associated macrophages and neutrophils.
FACS / Human
Reversible senescence in human CD4+CD45RA+CD27- memory T cells.
FACS / Human
High frequency, sustained T cell responses to PARV4 suggest viral persistence in vivo.
FACS / Human
Changing survival, memory cell compartment, and T-helper balance of lymphocytes between severe and mild asthma.
ICC/IF / Human
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