anti-CD49f / Integrin alpha 6 antibody [Mab-5A] (PE)

Key features and details

  • 产品描述: PE-conjugated Mouse Monoclonal antibody [Mab-5A] recognizes CD49f / Integrin alpha 6
  • 反应物种: Rat
  • 应用: FACS
  • 宿主: Mouse
  • 克隆: Monoclonal
  • 克隆号: Mab-5A
  • 同位型: IgG1
  • 靶点名称: CD49f / Integrin alpha 6
  • 抗原物种: Rat
  • Brand:
CAT.NO. : ARG22734
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Product Details
概述
产品描述PE-conjugated Mouse Monoclonal antibody [Mab-5A] recognizes CD49f / Integrin alpha 6
反应物种Rat
应用FACS
宿主Mouse
克隆Monoclonal
克隆号Mab-5A
同位型IgG1
靶点名称CD49f / Integrin alpha 6
抗原物种Rat
抗原Rat oesophageal carcinoma cell line B2T.
偶联标记PE
別名CD49 antigen-like family member F; ITGA6B; Alpha6p; VLA-6; CD antigen CD49f; CD49f; Integrin alpha-6
应用说明
应用建议
应用推荐稀释比
FACSAssay-dependent
应用说明FACS: Use 10 µl of the suggested working dilution to label 10^6 cells in 100 µl.
* The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.
属性
形式Liquid
纯化Purification with Protein G.
缓冲液PBS, 0.09% Sodium azide, 1% BSA and 5% Sucrose.
抗菌剂0.09% Sodium azide
稳定剂1% BSA and 5% Sucrose
存放说明Aliquot and store in the dark at 2-8°C. Keep protected from prolonged exposure to light. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
注意事项For laboratory research only, not for drug, diagnostic or other use.
生物信息
基因名称ITGA6
全名integrin, alpha 6
背景介绍The ITGA6 protein product is the integrin alpha chain alpha 6. Integrins are integral cell-surface proteins composed of an alpha chain and a beta chain. A given chain may combine with multiple partners resulting in different integrins. For example, alpha 6 may combine with beta 4 in the integrin referred to as TSP180, or with beta 1 in the integrin VLA-6. Integrins are known to participate in cell adhesion as well as cell-surface mediated signalling. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
生物功能Integrin alpha-6/beta-1 is a receptor for laminin on platelets. Integrin alpha-6/beta-4 is a receptor for laminin in epithelial cells and it plays a critical structural role in the hemidesmosome. [UniProt]
预测分子量127 kDa
翻译后修饰Isoforms containing segment A, but not segment B, are the major targets for PMA-induced phosphorylation. Phosphorylation occurs on 'Ser-1103' of isoform alpha-6X1X2A. Phosphorylation is not required for the induction of integrin alpha-6A/beta-1 high affinity but may reduce the affinity for ligand.
In invasive prostate cancer ITGA6 undergoes PLAU-mediated cleavage at residues Arg-634-635-Arg in a time-dependent manner enhancing cell invasion and migration in vitro.
Palmitoylation by DHHC3 enhances stability and cell surface expression.
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