anti-CD5 antibody [CRIS1] (APC)
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Key features and details
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CAT.NO. : ARG53867
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Product Details
概述
| 产品描述 | APC-conjugated Mouse Monoclonal antibody [CRIS1] recognizes CD5 |
|---|---|
| 反应物种 | Hu |
| 应用 | FACS |
| 特异性 | The clone CRIS1 reacts with the cell surface glycoprotein CD5, a 67kDa single-chain transmembrane glycoprotein expressed on mature T lymphocytes, most of thymocytes and B lymphocytes subset (B-1a lymphocytes). HLDA I; WS Code T 29 HLDA III; WS Code T 530 |
| 宿主 | Mouse |
| 克隆 | Monoclonal |
| 克隆号 | CRIS1 |
| 同位型 | IgG2a |
| 靶点名称 | CD5 |
| 抗原物种 | Human |
| 抗原 | stimulated human leukocytes |
| 偶联标记 | APC |
| 別名 | CD antigen CD5; Lymphocyte antigen T1/Leu-1; LEU1; T-cell surface glycoprotein CD5; T1 |
应用说明
| 应用建议 |
| ||||
|---|---|---|---|---|---|
| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 纯化说明 | The purified antibody is conjugated with cross-linked Allophycocyanin (APC) under optimum conditions. The conjugate is purified by size-exclusion chromatography and adjusted for direct use. No reconstitution is necessary. |
| 缓冲液 | PBS, 15 mM Sodium azide and 0.2% (w/v) high-grade protease free BSA |
| 抗菌剂 | 15 mM Sodium azide |
| 稳定剂 | 0.2% (w/v) high-grade protease free BSA |
| 存放说明 | Aliquot and store in the dark at 2-8°C. Keep protected from prolonged exposure to light. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | CD5 |
| 全名 | CD5 molecule |
| 背景介绍 | CD5 antigen (T1; 67 kDa) is a human cell surface T-lymphocyte single-chain transmembrane glycoprotein. CD5 is expressed on all mature T-lymphocytes, most of thymocytes, subset of B-lymphocytes and on many T-cell leukemias and lymphomas. It is a type I membrane glycoprotein whose extracellular region contains three scavenger receptor cysteine-rich (SRCR) domains. The CD5 is a signal transducing molecule whose cytoplasmic tail is devoid of any intrinsic catalytic activity. CD5 modulates signaling through the antigen-specific receptor complex (TCR and BCR). CD5 crosslinking induces extracellular Ca++ mobilization, tyrosine phosphorylation of intracellular proteins and DAG production. Preliminary evidence shows protein associations with ZAP-70, p56lck, p59fyn, PC-PLC, etc. CD5 may serve as a dual receptor, giving either stimulatory or inhibitory signals depending both on the cell type and development stage. In thymocytes and B1a cells seems to provide inhibitory signals, in peripheral mature T lymhocytes it acts as a costimulatory signal receptor. CD5 is the phenotypic marker of a B cell subpopulation involvedin the production of autoreactive antibodies. Disease relevance: CD5 is a phenotypic marker for some B cell lymphoproliferative disorders (B-CLL, Hairy cell leukemia, etc.). The CD5+ popuation is expanded in some autoimmune disorders (Rheumatoid Arthritis, etc.). Herpes virus infections induce loss of CD5 expression in the expanded CD8+ human T cells. |
| 生物功能 | May act as a receptor in regulating T-cell proliferation. [UniProt] |
| 研究领域 | Developmental Biology antibody; Immune System antibody |
| 预测分子量 | 55 kDa |
| 翻译后修饰 | Phosphorylated on tyrosine residues by LYN; this creates binding sites for PTPN6/SHP-1. |
检测图片 (1)
ARG53867 anti-CD5 antibody [CRIS1] (APC) FACS image
Flow Cytometry: Human peripheral blood stained with ARG53867 anti-CD5 antibody [CRIS1] (APC).
参考文献
克隆号文献
Conformation of the hypervariable region L3 without the key proline residue.
The clusters of differentiation (CD) defined by the First International Workshop on Human Leucocyte Differentiation Antigens.
Cellular immunity analysis using monoclonal antibodies in human glomerulonephritis.
Intracellular events involved in CD5-induced human T cell activation and proliferation.
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