anti-CD50 / ICAM3 antibody [MEM-04] (low endotoxin)

产品描述: Azide free and low endotoxin Mouse Monoclonal antibody [MEM-04] recognizes CD50 / ICAM3
反应物种: Hu
应用: FACS, FuncSt, IHC-P
特异性: The antibody MEM-04 reacts with an extracellular epitope of CD50 (ICAM-3), a 120-130 kDa type I membrane protein (immunoglobulin supergene family) expressed on leukocytes, endothelial cells and Langerhans cells; it is negative on platelets and erythrocytes. The MEM-04 blocks DC-SIGN (CD209) binding to ICAM-3 (epitope in D1).
宿主: Mouse
克隆: Monoclonal
克隆号: MEM-04
同位型: IgG1
靶点名称: CD50 / ICAM3

CAT.NO. : ARG42245

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Size:

100 μg

Product Details

概述

产品描述	Azide free and low endotoxin Mouse Monoclonal antibody [MEM-04] recognizes CD50 / ICAM3
反应物种	Hu
应用	FACS, FuncSt, IHC-P
特异性	The antibody MEM-04 reacts with an extracellular epitope of CD50 (ICAM-3), a 120-130 kDa type I membrane protein (immunoglobulin supergene family) expressed on leukocytes, endothelial cells and Langerhans cells; it is negative on platelets and erythrocytes. The MEM-04 blocks DC-SIGN (CD209) binding to ICAM-3 (epitope in D1).
宿主	Mouse
克隆	Monoclonal
克隆号	MEM-04
同位型	IgG1
靶点名称	CD50 / ICAM3
抗原物种	Human
抗原	Leukocytes of a patient suffering from LGL-type leukemia.
偶联标记	Un-conjugated
別名	CD50; CD antigen CD50; Intercellular adhesion molecule 3; ICAM-3; ICAM-R; CDw50; CDW50

应用说明

应用建议

应用说明

* The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.

属性

形式	Liquid
纯化	Purification with Protein A.
纯化说明	0.2 µm filter sterilized. Endotoxin level is less than 0.01 EU/µg of the protein.
缓冲液	PBS
浓度	1 mg/ml
存放说明	For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
注意事项	For laboratory research only, not for drug, diagnostic or other use.

生物信息

数据库连接	GeneID: 3385 Human ICAM3 Swiss-port # P32942 Human Intercellular adhesion molecule 3
基因名称	ICAM3
全名	intercellular adhesion molecule 3
背景介绍	The protein encoded by this gene is a member of the intercellular adhesion molecule (ICAM) family. All ICAM proteins are type I transmembrane glycoproteins, contain 2-9 immunoglobulin-like C2-type domains, and bind to the leukocyte adhesion LFA-1 protein. This protein is constitutively and abundantly expressed by all leucocytes and may be the most important ligand for LFA-1 in the initiation of the immune response. It functions not only as an adhesion molecule, but also as a potent signalling molecule. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Feb 2016]
生物功能	ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2) (PubMed:1448173). ICAM3 is also a ligand for integrin alpha-D/beta-2. In association with integrin alpha-L/beta-2, contributes to apoptotic neutrophil phagocytosis by macrophages (PubMed:23775590). [UniProt]
细胞定位	Membrane; Single-pass type I membrane protein. [UniProt]
预测分子量	60 kDa
翻译后修饰	Upon stimulation by a physiologic stimuli becomes rapidly and transiently phosphorylated on serine residues. N-glycosylated; glycans consist of a mixture of tri- and tetra-antennary complex-type chains and high-mannose chains. [UniProt]

检测图片 (1)

ARG42245 anti-CD50 / ICAM3 antibody [MEM-04] (low endotoxin) IHC-P image
Immunohistochemistry: Paraffin-embedded Human tonsil tissue stained with ARG42245 anti-CD50 / ICAM3 antibody [MEM-04] (low endotoxin).

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