anti-CD51 / Integrin alpha V antibody [13C2] (FITC)

Key features and details

  • 产品描述: FITC-conjugated Mouse Monoclonal antibody [13C2] recognizes CD51 / Integrin alpha V
  • 反应物种: Hu, AGMK, Bov, Rb
  • 应用: BL, Depletion, ELISA, FACS, ICC/IF, IHC-Fr, Puri
  • 特异性: Human/African Green Monkey/Rabbit/Bovine CD51.
  • 宿主: Mouse
  • 克隆: Monoclonal
  • 克隆号: 13C2
  • 同位型: IgG1, kappa
  • 靶点名称: CD51 / Integrin alpha V
  • Brand:
CAT.NO. : ARG21382
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Product Details
概述
产品描述FITC-conjugated Mouse Monoclonal antibody [13C2] recognizes CD51 / Integrin alpha V
反应物种Hu, AGMK, Bov, Rb
应用BL, Depletion, ELISA, FACS, ICC/IF, IHC-Fr, Puri
特异性Human/African Green Monkey/Rabbit/Bovine CD51.
宿主Mouse
克隆Monoclonal
克隆号13C2
同位型IgG1, kappa
靶点名称CD51 / Integrin alpha V
抗原物种Human
抗原Cell suspension containing osteoclasts from osteoclastomas
偶联标记FITC
別名CD51; VNRA; CD antigen CD51; VTNR; Vitronectin receptor subunit alpha; Integrin alpha-V; MSK8
应用说明
应用建议
应用推荐稀释比
BLAssay-dependent
DepletionAssay-dependent
ELISAAssay-dependent
FACS10 µl/10^6 cells
ICC/IFAssay-dependent
IHC-FrAssay-dependent
PuriAssay-dependent
应用说明* The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.
属性
形式Liquid
缓冲液PBS and 0.1% Sodium azide.
抗菌剂0.1% Sodium azide
存放说明Aliquot and store in the dark at 2-8°C. Keep protected from prolonged exposure to light. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
注意事项For laboratory research only, not for drug, diagnostic or other use.
生物信息
数据库连接

GeneID: 281875 Bovine ITGAV

GeneID: 3685 Human ITGAV

Swiss-port # P06756 Human Integrin alpha-V

Swiss-port # P80746 Bovine Integrin alpha-V

基因名称ITGAV
全名integrin, alpha V
背景介绍This gene encodes a protein that is a member of the integrin superfamily. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This protein undergoes post-translational cleavage to yield disulfide-linked heavy and light chains that combine with multiple integrin beta chains to form different integrins. This protein has been shown to heterodimerize with beta 1, beta 3, beta 5, beta 6, and beta 8; the heterodimer of alpha v and beta 3 is the Vitronectin receptor. This protein interacts with several extracellular matrix proteins to mediate cell adhesion and may play a role in cell migration. It is proposed that this protein may regulate angiogenesis and cancer progression. Alternative splicing results in multiple transcript variants that encode different protein isoforms. Note that the integrin alpha 5 and integrin alpha V chains are produced by distinct genes. [provided by RefSeq, Jan 2015]
生物功能The alpha-V (ITGAV) integrins are receptors for vitronectin, cytotactin, fibronectin, fibrinogen, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin and vWF. They recognize the sequence R-G-D in a wide array of ligands. In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions. [UniProt]
预测分子量116 kDa
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