anti-CD62P / P-Selectin antibody [AK-6]
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Key features and details
- 产品描述:
- 反应物种:
- 应用:
- 宿主:
- 克隆:
- 克隆号:
- 同位型:
- 靶点名称:
- 抗原物种:
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Brand:
CAT.NO. : ARG23102
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Product Details
概述
| 产品描述 | Mouse Monoclonal antibody [AK-6] recognizes CD62P / P-Selectin Mouse anti Human CD62P antibody, clone AK-6 recognizes the CD62P glycoprotein, a 140kD molecule expressed by activated platelets and endothelial cells.CD62P is also known as P-selectin, PADGEM or GMP140 and plays an important role in adhesive processes between leucocytes and endothelial cells. CD62P is a component of the alpha granule and is translocated to the plasma membrane upon activation. |
|---|---|
| 反应物种 | Hu, R. Mk |
| 应用 | FACS, ICC/IF, IHC-Fr, IHC-P, WB |
| 宿主 | Mouse |
| 克隆 | Monoclonal |
| 克隆号 | AK-6 |
| 同位型 | IgG1 |
| 靶点名称 | CD62P / P-Selectin |
| 抗原物种 | Human |
| 抗原 | Human platelet membrane glycoproteins. |
| 偶联标记 | Un-conjugated |
| 別名 | PADGEM; CD62; Platelet activation dependent granule-external membrane protein; CD62 antigen-like family member P; GMP140; PSEL; Granule membrane protein 140; CD62P; CD antigen CD62P; Leukocyte-endothelial cell adhesion molecule 3; GRMP; GMP-140; P-selectin; LECAM3 |
应用说明
| 应用建议 |
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|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 应用说明 | IHC-P: Staining may be enhanced using Sodium Citrate buffer pH 6.0 FACS: Use 10 µl of the suggested working dilution to label 10^6 cells in 100 µl. * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Purification with Protein G. |
| 缓冲液 | PBS and 0.09% Sodium azide |
| 抗菌剂 | 0.09% Sodium azide |
| 浓度 | 1 mg/ml |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | SELP |
| 全名 | selectin P (granule membrane protein 140kDa, antigen CD62) |
| 背景介绍 | This gene encodes a 140 kDa protein that is stored in the alpha-granules of platelets and Weibel-Palade bodies of endothelial cells. This protein redistributes to the plasma membrane during platelet activation and degranulation and mediates the interaction of activated endothelial cells or platelets with leukocytes. The membrane protein is a calcium-dependent receptor that binds to sialylated forms of Lewis blood group carbohydrate antigens on neutrophils and monocytes. Alternative splice variants may occur but are not well documented. [provided by RefSeq, Jul 2008] |
| 生物功能 | Ca(2+)-dependent receptor for myeloid cells that binds to carbohydrates on neutrophils and monocytes. Mediates the interaction of activated endothelial cells or platelets with leukocytes. The ligand recognized is sialyl-Lewis X. Mediates rapid rolling of leukocyte rolling over vascular surfaces during the initial steps in inflammation through interaction with PSGL1. [UniProt] |
| 预测分子量 | 91 kDa |
检测图片 (3)
ARG23102 anti-CD62P / P-Selectin antibody [AK-6] FACS image
Flow Cytometry: Human peripheral blood platelets stained with ARG23102 anti-CD62P / P-Selectin antibody [AK-6].
ARG23102 anti-CD62P / P-Selectin antibody [AK-6] IHC-P image
Immunohistochemistry: Formalin-fixed and paraffin-embedded Human tonsil stained with ARG23102 anti-CD62P / P-Selectin antibody [AK-6].
ARG23102 anti-CD62P / P-Selectin antibody [AK-6] FACS image
Flow Cytometry: Thrombin activated platelets stained with ARG23102 anti-CD62P / P-Selectin antibody [AK-6].
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