anti-CD68 antibody [SP251]

Key features and details

  • 产品描述: Rabbit Monoclonal antibody [SP251] recognizes CD68
  • 反应物种: Hu
  • 应用: FACS, IHC-P
  • 宿主: Rabbit
  • 克隆: Monoclonal
  • 克隆号: SP251
  • 同位型: IgG
  • 靶点名称: CD68
  • 抗原物种: Human
  • Brand:
CAT.NO. : ARG52803
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Product Details
概述
产品描述Rabbit Monoclonal antibody [SP251] recognizes CD68
反应物种Hu
应用FACS, IHC-P
宿主Rabbit
克隆Monoclonal
克隆号SP251
同位型IgG
靶点名称CD68
抗原物种Human
抗原Synthetic peptide derived from the internal region of the human CD68 protein.
偶联标记Un-conjugated
別名Macrosialin; CD antigen CD68; LAMP4; Gp110; GP110; SCARD1
应用说明
应用建议
应用推荐稀释比
FACSAssay-Dependent
IHC-P1:100
应用说明IHC-P: Antigen Retrieval: Boil tissue section in 10mM citrate buffer, pH 6.0 for 10 min followed by cooling at RT for 20 min.
Incubation Time: 10 at RT.
* The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.
阳性对照Tonsil
属性
形式Liquid
纯化Purified by protein A/G
缓冲液PBS (pH 7.6), 1% BSA and
抗菌剂
稳定剂1% BSA
存放说明For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
注意事项For laboratory research only, not for drug, diagnostic or other use.
生物信息
数据库连接

GeneID: 968 Human CD68

Swiss-port # P34810 Human Macrosialin

背景介绍CD68 is a 110-kD transmembrane glycoprotein that is highly expressed by human monocytes and tissue macrophages. It is a member of the lysosomal/endosomal-associated membrane glycoprotein (LAMP) family. The protein primarily localizes to lysosomes and endosomes with a smaller fraction circulating to the cell surface. It is a type I integral membrane protein with a heavily glycosylated extracellular domain and binds to tissue- and organ-specific lectins or selectins. The protein is also a member of the scavenger receptor family. Scavenger receptors typically function to clear cellular debris, promote phagocytosis, and mediate the recruitment and activation of macrophages. Alternative splicing results in multiple transcripts encoding different isoforms. [provided by RefSeq, Jul 2008]
生物功能CD68 could play a role in phagocytic activities of tissue macrophages, both in intracellular lysosomal metabolism and extracellular cell-cell and cell-pathogen interactions. Binds to tissue- and organ-specific lectins or selectins, allowing homing of macrophage subsets to particular sites. Rapid recirculation of CD68 from endosomes and lysosomes to the plasma membrane may allow macrophages to crawl over selectin-bearing substrates or other cells. [UniProt]
细胞定位Cytoplasm
产品亮点Related products:
CD68 antibodies; CD68 Duos / Panels; Anti-Rabbit IgG secondary antibodies;
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预测分子量37 kDa
翻译后修饰N- and O-glycosylated.
检测图片 (2)
  • ARG52803 anti-CD68 antibody [SP251] FACS image

    Flow Cytometry: Raji cells stained with ARG52803 anti-CD68 antibody [SP251] (green) compare to negative control of Rabbit IgG (blue).

  • ARG52803 anti-CD68 antibody [SP251] IHC-P image

    Immunohistochemistry: Human Tonsil stained with CD68 antibody [SP251] (ARG52803)

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