anti-CD81 antibody [M38] (FITC)

Key features and details

  • 产品描述: FITC-conjugated Mouse Monoclonal antibody [M38] recognizes CD81
  • 反应物种: Hu, Cat, Rb
  • 应用: FACS
  • 特异性: The clone M38 reacts with CD81, a 25 kDa member of the tetraspanin family, expressed on majority of cells.
  • 宿主: Mouse
  • 克隆: Monoclonal
  • 克隆号: M38
  • 同位型: IgG1
  • 靶点名称: CD81
  • Brand:
CAT.NO. : ARG62935
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Product Details
概述
产品描述FITC-conjugated Mouse Monoclonal antibody [M38] recognizes CD81
反应物种Hu, Cat, Rb
应用FACS
特异性The clone M38 reacts with CD81, a 25 kDa member of the tetraspanin family, expressed on majority of cells.
宿主Mouse
克隆Monoclonal
克隆号M38
同位型IgG1
靶点名称CD81
抗原物种Human
抗原MOLT-4 (human T-ALL cell line)
偶联标记FITC
別名CD antigen CD81; TAPA1; Tspan-28; S5.7; CD81 antigen; Target of the antiproliferative antibody 1; Tetraspanin-28; 26 kDa cell surface protein TAPA-1; CVID6; TSPAN28
应用说明
应用建议
应用推荐稀释比
FACS20 µl / 10^6 cells
应用说明* The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.
属性
形式Liquid
纯化说明The purified antibody is conjugated with Fluorescein isothiocyanate (FITC) under optimum conditions. The reagent is free of unconjugated FITC and adjusted for direct use. No reconstitution is necessary.
缓冲液PBS, 15 mM Sodium azide and 0.2% (w/v) high-grade protease free BSA
抗菌剂15 mM Sodium azide
稳定剂0.2% (w/v) high-grade protease free BSA
存放说明Aliquot and store in the dark at 2-8°C. Keep protected from prolonged exposure to light. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
注意事项For laboratory research only, not for drug, diagnostic or other use.
生物信息
数据库连接

GeneID: 975 Human CD81

Swiss-port # P60033 Human CD81 antigen

基因名称CD81
全名CD81 molecule
背景介绍CD81 (TAPA-1), a member of the tetraspanin family, is expressed on virtually all nucleated cells, but above all on germinal center B cells. CD81 forms complexes with other tetraspanin proteins, integrins, coreceptors, MHC class I and II molecules, and influences adhesion, morphology, activation, proliferation and differentiation of B, T and other cells – e.g. in muscles CD81 promotes cell fusion and myotube maintenance. CD81 has been also identified as a receptor for the hepatitis C virus.
生物功能May play an important role in the regulation of lymphoma cell growth. Interacts with a 16-kDa Leu-13 protein to form a complex possibly involved in signal transduction. May act as the viral receptor for HCV. [UniProt]
产品亮点Related products:
CD81 antibodies; Anti-Mouse IgG secondary antibodies;
Related news:
Tools for studying Exosomes
研究领域Immune System antibody; Microbiology and Infectious Disease antibody
预测分子量26 kDa
翻译后修饰Not glycosylated.
检测图片 (2)
  • ARG62935 anti-CD81 antibody [M38] (FITC) FACS image

    Flow Cytometry: Human peripheral whole blood stained with ARG62935 anti-CD81 antibody [M38] (FITC) (20 µl reagent / 100 µl of peripheral whole blood).

  • ARG62935 anti-CD81 antibody [M38] (FITC) FACS image

    Flow Cytometry: Separation of lymphocytes (red-filled) from neutrophil granulocytes (black-dashed). Human peripheral whole blood stained with ARG62935 anti-CD81 antibody [M38] (FITC) (20 µl reagent / 100 µl of peripheral whole blood).

参考文献

克隆号文献

Selective enrichment of tetraspan proteins on the internal vesicles of multivesicular endosomes and on exosomes secreted by human B-lymphocytes.

Escola JM et al.
J Biol Chem.,  (1998)

publication_link

 

hr_line

C33 antigen and M38 antigen recognized by monoclonal antibodies inhibitory to syncytium formation by human T cell leukemia virus type 1 are both members of the transmembrane 4 superfamily and associate with each other and with CD4 or CD8 in T cells.

Imai T et al.
J Immunol.,  (1993)

publication_link

 

hr_line

Identification of membrane antigen C33 recognized by monoclonal antibodies inhibitory to human T-cell leukemia virus type 1 (HTLV-1)-induced syncytium formation: altered glycosylation of C33 antigen in HTLV-1-positive T cells.

Fukudome K et al.
J Virol.,  (1992)

publication_link

 

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