anti-CEACAM3 antibody
Key features and details
- 产品描述:
- 反应物种:
- 应用:
- 宿主:
- 克隆:
- 同位型:
- 靶点名称:
- 抗原物种:
- 抗原:
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Brand:
CAT.NO. : ARG58379
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Product Details
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes CEACAM3 |
|---|---|
| 反应物种 | Hu, Ms |
| 应用 | WB |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | CEACAM3 |
| 抗原物种 | Human |
| 抗原 | Recombinant fusion protein corresponding to aa. 1-135 of Human CEACAM3 (NP_001806.2). |
| 偶联标记 | Un-conjugated |
| 別名 | CGM1; W282; Carcinoembryonic antigen CGM1; CEA; Carcinoembryonic antigen-related cell adhesion molecule 3; W264; CD66D; CD antigen CD66d |
应用说明
| 应用建议 |
| ||||
|---|---|---|---|---|---|
| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||
| 阳性对照 | Mouse lung | ||||
| 实际分子量 | 27 kDa |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Affinity purified. |
| 缓冲液 | PBS (pH 7.3), 0.02% Sodium azide and 50% Glycerol. |
| 抗菌剂 | 0.02% Sodium azide |
| 稳定剂 | 50% Glycerol |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | Swiss-port # P40198 Human Carcinoembryonic antigen-related cell adhesion molecule 3 |
|---|---|
| 基因名称 | CEACAM3 |
| 全名 | carcinoembryonic antigen-related cell adhesion molecule 3 |
| 背景介绍 | This gene encodes a member of the family of carcinoembryonic antigen-related cell adhesion molecules (CEACAMs), which are used by several bacterial pathogens to bind and invade host cells. The encoded transmembrane protein directs phagocytosis of several bacterial species that is dependent on the small GTPase Rac. It is thought to serve an important role in controlling human-specific pathogens by the innate immune system. Alternatively spliced transcript variants have been described. [provided by RefSeq, Mar 2013] |
| 生物功能 | Major granulocyte receptor mediating recognition and efficient opsonin-independent phagocytosis of CEACAM-binding microorganisms, including Neissiria, Moxarella and Haemophilus species, thus playing an important role in the clearance of pathogens by the innate immune system. Responsible for RAC1 stimulation in the course of pathogen phagocytosis. [UniProt] |
| 细胞定位 | Membrane, Single-pass type I membrane protein. [UniProt] |
| 预测分子量 | 27 kDa |
| 翻译后修饰 | Tyrosine-phosphorylated in response to microbial binding. Tyr-230 and Tyr-241 are both required for phosphorylation to be detected. [UniProt] |
检测图片 (1)
ARG58379 anti-CEACAM3 antibody WB image
Western blot: 25 µg of Mouse lung lysate stained with ARG58379 anti-CEACAM3 antibody at 1:1000 dilution.
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