anti-CLASP2 antibody [KT68]
![anti-CLASP2 antibody [KT68]](/upload/image/products/ARG42040_WB_1_210_205.jpg)
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Key features and details
- 产品描述:
- 反应物种:
- 应用:
- 宿主:
- 克隆:
- 克隆号:
- 同位型:
- 靶点名称:
- 抗原物种:
-
Brand:
CAT.NO. : ARG42040
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Product Details
概述
| 产品描述 | Rat Monoclonal antibody [KT68] recognizes CLASP2 |
|---|---|
| 反应物种 | Hu, Ms, Rat |
| 应用 | ICC/IF, WB |
| 宿主 | Rat |
| 克隆 | Monoclonal |
| 克隆号 | KT68 |
| 同位型 | IgG2b |
| 靶点名称 | CLASP2 |
| 抗原物种 | Mouse |
| 抗原 | GST fusion protein around the N-terminus of Mouse CLASP2. |
| 偶联标记 | Un-conjugated |
| 別名 | Cytoplasmic linker-associated protein 2; Protein Orbit homolog 2; hOrbit2; CLIP-associating protein 2 |
应用说明
| 应用建议 |
| ||||||
|---|---|---|---|---|---|---|---|
| 应用说明 | WB: Antibody is suggested to be diluted in 5% skimmed milk/Tris buffer with 0.04% Tween20 and incubated for 1 hour at room temperature. * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Purification with Protein G. |
| 缓冲液 | PBS and 0.05% Sodium azide. |
| 抗菌剂 | 0.05% Sodium azide |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | CLASP2 |
| 全名 | cytoplasmic linker associated protein 2 |
| 生物功能 | Microtubule plus-end tracking protein that promotes the stabilization of dynamic microtubules. Involved in the nucleation of noncentrosomal microtubules originating from the trans-Golgi network (TGN). Required for the polarization of the cytoplasmic microtubule arrays in migrating cells towards the leading edge of the cell. May act at the cell cortex to enhance the frequency of rescue of depolymerizing microtubules by attaching their plus-ends to cortical platforms composed of ERC1 and PHLDB2. This cortical microtubule stabilizing activity is regulated at least in part by phosphatidylinositol 3-kinase signaling. Also performs a similar stabilizing function at the kinetochore which is essential for the bipolar alignment of chromosomes on the mitotic spindle. Acts as a mediator of ERBB2-dependent stabilization of microtubules at the cell cortex. [UniProt] |
| 细胞定位 | Cytoplasm, cytoskeleton, spindle, microtubule organizing center, centrosome. Chromosome, centromere, kinetochore. Golgi apparatus, trans-Golgi network. Cell membrane. Cell projection, ruffle membrane. [UniProt] |
| 预测分子量 | 141 kDa |
| 翻译后修饰 | Phosphorylated by GSK3B. Phosphorylation reduces MAPRE1 binding (PubMed:26003921). Phosphorylation by GSK3B may negatively regulate binding to microtubule lattices in lamella. [UniProt] |
检测图片 (2)
ARG42040 anti-CLASP2 antibody [KT68] ICC/IF image
Immunofluorescence: Paraformaldehyde-fixed and NP40-permeabilized A431 cells stained with ARG42040 anti-CLASP2 antibody [KT68].
ARG42040 anti-CLASP2 antibody [KT68] WB image
Western blot: Mouse brain and PC-12 cell lysates stained with ARG42040 anti-CLASP2 antibody [KT68] at 1:500 dilution.
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