anti-CLEC4M / DC-SIGNR / L-SIGN antibody
Key features and details
- 产品描述:
- 反应物种:
- 预测物种:
- 应用:
- 宿主:
- 克隆:
- 同位型:
- 靶点名称:
- 抗原物种:
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Brand:
CAT.NO. : ARG42067
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Product Details
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes CLEC4M / DC-SIGNR / L-SIGN |
|---|---|
| 反应物种 | Hu |
| 预测物种 | Pig |
| 应用 | IHC-P, WB |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | CLEC4M / DC-SIGNR / L-SIGN |
| 抗原物种 | Human |
| 抗原 | Synthetic peptide around the N-terminal region of Human CLEC4M. (within the following region: LVLQL LSFML LAGVL VAILV QVSKV PSSLS QEQSE QDAIY QNLTQ LKAAV) |
| 偶联标记 | Un-conjugated |
| 別名 | LSIGN; DC-SIGNR; CD209L; DCSIGNR; CD antigen CD299; Dendritic cell-specific ICAM-3-grabbing non-integrin 2; CD299; DC-SIGN-related protein; L-SIGN; Liver/lymph node-specific ICAM-3-grabbing non-integrin; HP10347; C-type lectin domain family 4 member M; DC-SIGN2; CD209 antigen-like protein 1 |
应用说明
| 预测反应性说明 | Predicted Homology Based On Immunogen Sequence: Pig: 86% | ||||||
|---|---|---|---|---|---|---|---|
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||
| 阳性对照 | HepG2 | ||||||
| 实际分子量 | ~ 57 kDa |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Purification with Protein A. |
| 缓冲液 | PBS, 0.09% (w/v) Sodium azide and 2% Sucrose. |
| 抗菌剂 | 0.09% (w/v) Sodium azide |
| 稳定剂 | 2% Sucrose |
| 浓度 | Batch dependent: 0.5 - 1 mg/ml |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | Swiss-port # Q9H2X3 Human C-type lectin domain family 4 member M |
|---|---|
| 基因名称 | CLEC4M |
| 全名 | C-type lectin domain family 4, member M |
| 背景介绍 | This gene encodes a transmembrane receptor and is often referred to as L-SIGN because of its expression in the endothelial cells of the lymph nodes and liver. The encoded protein is involved in the innate immune system and recognizes numerous evolutionarily divergent pathogens ranging from parasites to viruses, with a large impact on public health. The protein is organized into three distinct domains: an N-terminal transmembrane domain, a tandem-repeat neck domain and C-type lectin carbohydrate recognition domain. The extracellular region consisting of the C-type lectin and neck domains has a dual function as a pathogen recognition receptor and a cell adhesion receptor by binding carbohydrate ligands on the surface of microbes and endogenous cells. The neck region is important for homo-oligomerization which allows the receptor to bind multivalent ligands with high avidity. Variations in the number of 23 amino acid repeats in the neck domain of this protein are common and have a significant impact on ligand binding ability. This gene is closely related in terms of both sequence and function to a neighboring gene (GeneID 30835; often referred to as DC-SIGN or CD209). DC-SIGN and L-SIGN differ in their ligand-binding properties and distribution. Alternative splicing results in multiple variants. [provided by RefSeq, Feb 2009] |
| 生物功能 | Probable pathogen-recognition receptor involved in peripheral immune surveillance in liver. May mediate the endocytosis of pathogens which are subsequently degraded in lysosomal compartments. Is a receptor for ICAM3, probably by binding to mannose-like carbohydrates. (Microbial infection) Acts as an attachment receptor for Ebolavirus, Hepatitis C virus, HIV-1, Human coronavirus 229E, Human cytomegalovirus/HHV-5, Influenzavirus, SARS coronavirus, West-nile virus, Japanese encephalitis virus and Marburg virus glycoprotein. (Microbial infection) Recognition of M. bovis by dendritic cells may occur partially via this molecule. [UniProt] |
| 细胞定位 | Isoform 1, 2 and 3: Cell membrane; Single-pass type II membrane protein. Isoform 5, 6, 7 and 10: Secreted. [UniProt] |
| 预测分子量 | 45 kDa |
检测图片 (2)
ARG42067 anti-CLEC4M / DC-SIGNR / L-SIGN antibody IHC-P image
Immunohistochemistry: Paraffin-embedded Human kidney tissue stained with ARG42067 anti-CLEC4M / DC-SIGNR / L-SIGN antibody.
ARG42067 anti-CLEC4M / DC-SIGNR / L-SIGN antibody WB image
Western blot: HepG2 cell lysate stained with ARG42067 anti-CLEC4M / DC-SIGNR / L-SIGN antibody at 1.25 µg/ml dilution.
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