anti-CLEC7A antibody [2A11] (Biotin)
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Key features and details
- 产品描述:
- 反应物种:
- 应用:
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- 克隆:
- 克隆号:
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- 靶点名称:
- 抗原物种:
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CAT.NO. : ARG22464
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Product Details
概述
| 产品描述 | Biotin-conjugated Rat Monoclonal antibody [2A11] recognizes CLEC7A This antibody recognizes murine beta-glucan receptor, also known as Dectin-1.Dectin-1 is predominantly expressed by cells of the monocyte/macrophage and neutrophil lineages, but also at lower levels by dendritic cells and a subpopulation of T cells.As a major leucocyte receptor for beta-glucan this molecule may have a key role in the immunomodulatory effects of beta-glucans and in the host response to fungal pathogens. Dectin-1 may stimulate reactive oxygen production in macropahges via the protein tyrosine kinase known as Syk. Rat anti Mouse Dectin-1 antibody, clone 2A11 inhibits the binding of zymosan to macrophages via the beta-glucan receptor. |
|---|---|
| 反应物种 | Ms |
| 应用 | FACS |
| 宿主 | Rat |
| 克隆 | Monoclonal |
| 克隆号 | 2A11 |
| 同位型 | IgG2b |
| 靶点名称 | CLEC7A |
| 抗原物种 | Mouse |
| 抗原 | Dectin-1 transfected NIH3T3 cells and recombinant soluble Dectin-1. |
| 偶联标记 | Biotin |
| 別名 | C-type lectin superfamily member 12; CD369; Dectin-1; Dendritic cell-associated C-type lectin 1; CLECSF12; CANDF4; BGR; Beta-glucan receptor; C-type lectin domain family 7 member A; DC-associated C-type lectin 1; DECTIN1 |
应用说明
| 应用建议 |
| ||||
|---|---|---|---|---|---|
| 应用说明 | FACS: Use 10ul of the suggested working dilution to label 10^6 cells in 100ul * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Purification with Protein G. |
| 缓冲液 | PBS, 0.09% Sodium azide and 1% BSA. |
| 抗菌剂 | 0.09% Sodium azide |
| 稳定剂 | 1% BSA |
| 浓度 | 0.1 mg/ml |
| 存放说明 | Aliquot and store in the dark at 2-8°C. Keep protected from prolonged exposure to light. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | Swiss-port # Q6QLQ4 Mouse C-type lectin domain family 7 member A |
|---|---|
| 基因名称 | Clec7a |
| 全名 | C-type lectin domain family 7, member a |
| 背景介绍 | This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. The encoded glycoprotein is a small type II membrane receptor with an extracellular C-type lectin-like domain fold and a cytoplasmic domain with an immunoreceptor tyrosine-based activation motif. It functions as a pattern-recognition receptor that recognizes a variety of beta-1,3-linked and beta-1,6-linked glucans from fungi and plants, and in this way plays a role in innate immune response. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. This gene is closely linked to other CTL/CTLD superfamily members on chromosome 12p13 in the natural killer gene complex region. [provided by RefSeq, Jul 2008] |
| 生物功能 | Lectin that functions as pattern receptor specific for beta-1,3-linked and beta-1,6-linked glucans, such as cell wall constituents from pathogenic bacteria and fungi. Necessary for the TLR2-mediated inflammatory response and for TLR2-mediated activation of NF-kappa-B. Enhances cytokine production in macrophages and dendritic cells. Mediates production of reactive oxygen species in the cell. Mediates phagocytosis of C.albicans conidia. Binds T-cells in a way that does not involve their surface glycans and plays a role in T-cell activation. Stimulates T-cell proliferation (By similarity). [UniProt] |
| 预测分子量 | 28 kDa |
| 翻译后修饰 | Phosphorylated on tyrosine residues in response to glucan binding. |
检测图片 (1)
ARG22464 anti-CLEC7A antibody [2A11] (Biotin) FACS image
Flow Cytometry: Mouse peripheral blood granulocytes stained with ARG22464 anti-CLEC7A antibody [2A11] (Biotin).
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