anti-CtIP (Ser327) antibody
Key features and details
- 产品描述:
- 反应物种:
- 预测物种:
- 应用:
- 宿主:
- 克隆:
- 同位型:
- 靶点名称:
- 抗原物种:
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Brand:
CAT.NO. : ARG44274
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Size:
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Product Details
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes CtIP phospho (Ser327) |
|---|---|
| 反应物种 | Hu |
| 预测物种 | NHuPrm |
| 应用 | WB |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | CtIP |
| 抗原物种 | Human |
| 抗原 | Synthetic phospho-peptide |
| 偶联标记 | Un-conjugated |
| 別名 | RBBP8; RB Binding Protein 8, Endonuclease; RIM; COM1; CTIP; Sporulation In The Absence Of SPO11 Protein 2 Homolog; Retinoblastoma-Binding Protein 8; Retinoblastoma Binding Protein 8; CTBP-Interacting Protein; DNA Endonuclease RBBP8; RBBP-8; SCKL2; CtIP; SAE2; Retinoblastoma-Interacting Protein And Myosin-Like; CtBP-Interacting Protein; Seckel Syndrome 2; EC 3.1.-.- ; JAWAD; JWDS |
应用说明
| 应用建议 |
| ||||
|---|---|---|---|---|---|
| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Antigen Affinity Purified |
| 缓冲液 | 10 mM HEPES (pH 7.5), 150 mM NaCl, 50% Glycerol and 100 µg/ml BSA. |
| 稳定剂 | 50% Glycerol and 100 µg/ml BSA |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | RBBP8 |
| 全名 | RB Binding Protein 8, Endonuclease |
| 背景介绍 | The protein encoded by this gene is a ubiquitously expressed nuclear protein. It is found among several proteins that bind directly to retinoblastoma protein, which regulates cell proliferation. This protein complexes with transcriptional co-repressor CTBP. It is also associated with BRCA1 and is thought to modulate the functions of BRCA1 in transcriptional regulation, DNA repair, and/or cell cycle checkpoint control. It is suggested that this gene may itself be a tumor suppressor acting in the same pathway as BRCA1. Three transcript variants encoding two different isoforms have been found for this gene. More transcript variants exist, but their full-length natures have not been determined. |
| 生物功能 | Endonuclease that cooperates with the MRE11-RAD50-NBN (MRN) complex in DNA-end resection, the first step of double-strand break (DSB) repair through the homologous recombination (HR) pathway. |
| 细胞定位 | Chromosome, Nucleus |
| 预测分子量 | 102 kDa |
| 翻译后修饰 | Isopeptide bond, Phosphoprotein, Ubl conjugation |
检测图片 (1)
ARG44274 anti-CtIP (Ser327) antibody WB image
Western blot: T47D stained with ARG44274 anti-CtIP (Ser327) antibody.
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