anti-Cyclophilin A antibody
Key features and details
- 产品描述:
- 反应物种:
- 预测物种:
- 应用:
- 特异性:
- 宿主:
- 克隆:
- 同位型:
- 靶点名称:
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Brand:
CAT.NO. : ARG63884
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Product Details
概述
| 产品描述 | Goat Polyclonal antibody recognizes Cyclophilin A |
|---|---|
| 反应物种 | Hu |
| 预测物种 | Ms, Rat, Cow, Dog, Pig |
| 应用 | WB |
| 特异性 | This product is expected to also recognise PPIAL (NP_001008741.1, GeneID: 388817) which is identical to PPIA (NP_066953.1). |
| 宿主 | Goat |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | Cyclophilin A |
| 抗原物种 | Human |
| 抗原 | C-ERFGSRNGKTSKK |
| 偶联标记 | Un-conjugated |
| 別名 | CYPA; Cyclosporin A-binding protein; PPIase A; CYPH; Cyclophilin A; HEL-S-69p; EC 5.2.1.8; Rotamase A; Peptidyl-prolyl cis-trans isomerase A |
应用说明
| 应用建议 |
| ||||
|---|---|---|---|---|---|
| 应用说明 | WB: Recommend incubate at RT for 1h. * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| 缓冲液 | Tris saline (pH 7.3), 0.02% Sodium azide and 0.5% BSA |
| 抗菌剂 | 0.02% Sodium azide |
| 稳定剂 | 0.5% BSA |
| 浓度 | 0.5 mg/ml |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | Swiss-port # P62937 Human Peptidyl-prolyl cis-trans isomerase A |
|---|---|
| 背景介绍 | This gene encodes a member of the peptidyl-prolyl cis-trans isomerase (PPIase) family. PPIases catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and accelerate the folding of proteins. The encoded protein is a cyclosporin binding-protein and may play a role in cyclosporin A-mediated immunosuppression. The protein can also interact with several HIV proteins, including p55 gag, Vpr, and capsid protein, and has been shown to be necessary for the formation of infectious HIV virions. Multiple pseudogenes that map to different chromosomes have been reported. [provided by RefSeq, Jul 2008] |
| 研究领域 | Immune System antibody; Signaling Transduction antibody |
| 预测分子量 | 18 kDa |
| 翻译后修饰 | Acetylation at Lys-125 markedly inhibits catalysis of cis to trans isomerization and stabilizes cis rather than trans forms of the HIV-1 capsid. PPIA acetylation also antagonizes the immunosuppressive effects of cyclosporine by inhibiting the sequential steps of cyclosporine binding and calcineurin inhibition. |
检测图片 (2)
ARG63884 anti-Cyclophilin A antibody WB image
Western blot: 35 µg of Human Lymph lysate stained with ARG63884 anti-Cyclophilin A antibody at 0.1 µg/ml dilution.
ARG63884 anti-Cyclophilin A antibody WB image
Western blot: 35 µg of Human lymph node lysate (in RIPA buffer) stained with ARG63884 anti-Cyclophilin A antibody at 0.1 µg/ml dilution and incubated at RT for 1 hour.
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