anti-EMR3 antibody [3D7]
![anti-EMR3 antibody [3D7]](/upload/image/20241105/8415bc38bc270b898ee2a90369a6c7fb.jpg)
Key features and details
- 产品描述:
- 反应物种:
- 应用:
- 宿主:
- 克隆:
- 克隆号:
- 同位型:
- 靶点名称:
- 抗原物种:
-
Brand:
CAT.NO. : ARG23156
US＄ Please choose
US＄ Please choose
Size:
Trail, Bulk size or Custom requests Please contact us
Product Details
概述
| 产品描述 | Hamster Monoclonal antibody [3D7] recognizes EMR3 Hamster anti Human EMR3 antibody, clone 3D7 recognizes human epidermal growth factor (EGF) module-containing mucin-like hormone receptor 3 (EMR3), a ~56 kDa member of the EGF-7 transmembrane (TM7) family of adhesion receptors. EMR3 is expressed at the cell surface as a heterodimer. The molecule is predominantly expressed on granulocytes, and at lower levels on mature myeloid cells, monocytes and dendritic cells. EMR3 is absent on lymphocytes, haematopoietic stem cells and myeloid progenitors. Studies suggest that the EMR3 molecule is up-regulated during late stages of neutrophil differentiation and is a marker for terminally differentiated cells. The exact functions of EMR3 and its ligands have not yet been determined. |
|---|---|
| 反应物种 | Hu |
| 应用 | FACS, IP |
| 宿主 | Hamster |
| 克隆 | Monoclonal |
| 克隆号 | 3D7 |
| 同位型 | IgG |
| 靶点名称 | EMR3 |
| 抗原物种 | Human |
| 抗原 | ARHO-EMR3-CD97 (EGF1) transfectants. |
| 偶联标记 | Un-conjugated |
| 別名 | EGF-like module receptor 3; EMR3; Adhesion G protein-coupled receptor E3; EGF-like module-containing mucin-like hormone receptor-like 3 |
应用说明
| 应用建议 |
| ||||||
|---|---|---|---|---|---|---|---|
| 应用说明 | FACS: Use 10 µl of the suggested working dilution to label 10^6 cells in 100 µl. * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Purification with Protein G. |
| 缓冲液 | PBS and 0.09% Sodium azide. |
| 抗菌剂 | 0.09% Sodium azide |
| 浓度 | 1 mg/ml |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | Swiss-port # Q9BY15 Human Adhesion G protein-coupled receptor E3 |
|---|---|
| 基因名称 | ADGRE3 |
| 全名 | adhesion G protein-coupled receptor E3 |
| 背景介绍 | This gene encodes a member of the class B seven-span transmembrane (TM7) receptor family expressed predominantly by cells of the immune system. Family members are characterized by an extended extracellular region with a variable number of N-terminal epidermal growth factor (EGF)-like domains coupled to a TM7 domain via a mucin-like spacer domain. This gene is closely linked to the gene encoding egf-like molecule containing mucin-like hormone receptor 2 on chromosome 19. This protein may play a role in myeloid-myeloid interactions during immune and inflammatory responses. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jan 2014] |
| 生物功能 | Orphan receptor that may play a role myeloid-myeloid interactions during immune and inflammatory responses. A ligand for the soluble form of this receptor is present at the surface of momocytes-derived macrophages and activated neutrophils. [UniProt] |
| 预测分子量 | 73 kDa |
| 翻译后修饰 | Proteolytically cleaved into 2 subunits, an extracellular alpha subunit and a seven-transmembrane subunit. [UniProt] |
New Products
