anti-Ephrin B2 phospho (Tyr316) antibody

Key features and details

  • 产品描述: Rabbit Polyclonal antibody recognizes Ephrin B2 phospho (Tyr316)
  • 反应物种: Hu, Ms
  • 应用: WB
  • 宿主: Rabbit
  • 克隆: Polyclonal
  • 同位型: IgG
  • 靶点名称: Ephrin B2
  • 抗原物种: Human
  • 抗原: Peptide sequence around phosphorylation site of tyrosine 316 (P-V-Y(p)-I-V) derived from Human Ephrin-B2
  • Brand:
CAT.NO. : ARG51683
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Product Details
概述
产品描述Rabbit Polyclonal antibody recognizes Ephrin B2 phospho (Tyr316)
反应物种Hu, Ms
应用WB
宿主Rabbit
克隆Polyclonal
同位型IgG
靶点名称Ephrin B2
抗原物种Human
抗原Peptide sequence around phosphorylation site of tyrosine 316 (P-V-Y(p)-I-V) derived from Human Ephrin-B2
偶联标记Un-conjugated
別名HTK ligand; HTKL; Htk-L; EPLG5; Ephrin-B2; HTK-L; LERK5; LERK-5; EPH-related receptor tyrosine kinase ligand 5
应用说明
应用建议
应用推荐稀释比
WB1:500 - 1:1000
应用说明* The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.
属性
形式Liquid
纯化Antibodies were produced by immunizing rabbits with KLH-conjugated synthetic peptide. Antibodies were purified by affinity-chromatography using epitope-specific peptide.
缓冲液PBS (without Mg2+ and Ca2+, pH 7.4), 150mM NaCl, 0.02% Sodium azide and 50% Glycerol.
抗菌剂0.02% Sodium azide
稳定剂50% Glycerol
浓度1 mg/ml
存放说明For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
注意事项For laboratory research only, not for drug, diagnostic or other use.
生物信息
数据库连接

GeneID: 13642 Mouse EFNB2

GeneID: 1948 Human EFNB2

Swiss-port # P52799 Human Ephrin-B2

Swiss-port # P52800 Mouse Ephrin-B2

基因名称EFNB2
全名ephrin-B2
背景介绍This gene product belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this protein is 99% identical to the mouse, rat and sheep orthologs. The encoded protein interacts with IRS1 protein, suggesting a role in regulating insulin sensitivity. Several transcript variants that differ in the 5' UTR but that encode the same protein have been identified for this gene.
生物功能Cell surface transmembrane ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Binds to receptor tyrosine kinase including EPHA4, EPHA3 and EPHB4. Together with EPHB4 plays a central role in heart morphogenesis and angiogenesis through regulation of cell adhesion and cell migration. EPHB4-mediated forward signaling controls cellular repulsion and segregation from EFNB2-expressing cells. May play a role in constraining the orientation of longitudinally projecting axons. [UniProt]
研究领域Cancer antibody; Cell Biology and Cellular Response antibody; Neuroscience antibody
预测分子量37 kDa
翻译后修饰Inducible phosphorylation of tyrosine residues in the cytoplasmic domain.
检测图片 (1)
  • ARG51683 anti-Ephrin B2 phospho (Tyr316) antibody WB image

    Western blot: Extracts from HT29 cells, untreated or treated with UV stained with ARG51683 anti-Ephrin B2 phospho (Tyr316) antibody.

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