anti-EXO1 antibody

Key features and details

  • 产品描述: Goat Polyclonal antibody recognizes EXO1
  • 反应物种: Hu
  • 应用: WB
  • 特异性: This antibody is expected to recognise all three reported isoforms (NP_003677.3; NP_006018.3 and NP_569082.1)
  • 宿主: Goat
  • 克隆: Polyclonal
  • 同位型: IgG
  • 靶点名称: EXO1
  • 抗原物种: Human
  • Brand:
CAT.NO. : ARG64475
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Product Details
概述
产品描述Goat Polyclonal antibody recognizes EXO1
反应物种Hu
应用WB
特异性This antibody is expected to recognise all three reported isoforms (NP_003677.3; NP_006018.3 and NP_569082.1)
宿主Goat
克隆Polyclonal
同位型IgG
靶点名称EXO1
抗原物种Human
抗原C-HRNYSPRPESGT
偶联标记Un-conjugated
別名Exonuclease I; hExoI; EC 3.1.-.-; hExo1; HEX1; Exonuclease 1
应用说明
应用建议
应用推荐稀释比
WB0.2 - 0.5 µg/ml
应用说明WB: Recommend incubate at RT for 1h.
* The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.
属性
形式Liquid
纯化Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
缓冲液Tris saline (pH 7.3), 0.02% Sodium azide and 0.5% BSA
抗菌剂0.02% Sodium azide
稳定剂0.5% BSA
浓度0.5 mg/ml
存放说明For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
注意事项For laboratory research only, not for drug, diagnostic or other use.
生物信息
数据库连接

GeneID: 9156 Human EXO1

Swiss-port # Q9UQ84 Human Exonuclease 1

背景介绍This gene encodes a protein with 5' to 3' exonuclease activity as well as an RNase H activity. It is similar to the Saccharomyces cerevisiae protein Exo1 which interacts with Msh2 and which is involved in mismatch repair and recombination. Alternative splicing of this gene results in three transcript variants encoding two different isoforms. [provided by RefSeq, Jul 2008]
研究领域Gene Regulation antibody
预测分子量94 kDa
翻译后修饰Phosphorylated upon DNA damage and in response to agents stalling DNA replication, probably by ATM or ATR. Phosphorylation at Ser-454, Thr-621 and Ser-714 is induced upon DNA-damage caused by treatment with hydroxyurea (HU) but not upon IR treatment. The HU-induced EXO1 triple phosphorylation facilitates destabilisation/degradation of the protein.
检测图片 (1)
  • ARG64475 anti-EXO1 antibody WB image

    Western Blot: A549 cell lysate (35 µg protein in RIPA buffer) stained with ARG64475 anti-EXO1 antibody at 0.2 µg/ml dilution.

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