anti-FCN1 antibody

Key features and details

  • 产品描述: Rabbit Polyclonal antibody recognizes FCN1
  • 反应物种: Hu, Ms, Rat
  • 应用: WB
  • 宿主: Rabbit
  • 克隆: Polyclonal
  • 同位型: IgG
  • 靶点名称: FCN1
  • 抗原物种: Human
  • 抗原: Recombinant fusion protein corresponding to aa. 30-326 of Human FCN1 (NP_001994.2).
  • Brand:
CAT.NO. : ARG58660
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Product Details
概述
产品描述Rabbit Polyclonal antibody recognizes FCN1
反应物种Hu, Ms, Rat
应用WB
宿主Rabbit
克隆Polyclonal
同位型IgG
靶点名称FCN1
抗原物种Human
抗原Recombinant fusion protein corresponding to aa. 30-326 of Human FCN1 (NP_001994.2).
偶联标记Un-conjugated
別名Ficolin-A; Collagen/fibrinogen domain-containing protein 1; Ficolin-alpha; Ficolin-1; M-ficolin; FCNM
应用说明
应用建议
应用推荐稀释比
WB1:500 - 1:2000
应用说明* The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.
实际分子量38 kDa
属性
形式Liquid
纯化Affinity purified.
缓冲液PBS (pH 7.3), 0.02% Sodium azide and 50% Glycerol.
抗菌剂0.02% Sodium azide
稳定剂50% Glycerol
存放说明For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
注意事项For laboratory research only, not for drug, diagnostic or other use.
生物信息
数据库连接

GeneID: 2219 Human FCN1

GeneID: 83517 Rat FCN1

Swiss-port # O00602 Human Ficolin-1

基因名称FCN1
全名ficolin (collagen/fibrinogen domain containing) 1
背景介绍The ficolin family of proteins are characterized by the presence of a leader peptide, a short N-terminal segment, followed by a collagen-like region, and a C-terminal fibrinogen-like domain. The collagen-like and the fibrinogen-like domains are also found separately in other proteins such as complement protein C1q, C-type lectins known as collectins, and tenascins. However, all these proteins recognize different targets, and are functionally distinct. Ficolin 1 encoded by FCN1 is predominantly expressed in the peripheral blood leukocytes, and has been postulated to function as a plasma protein with elastin-binding activity. [provided by RefSeq, Jul 2008]
生物功能Extracellular lectin functioning as a pattern-recognition receptor in innate immunity. Binds the sugar moieties of pathogen-associated molecular patterns (PAMPs) displayed on microbes and activates the lectin pathway of the complement system. May also activate monocytes through a G protein-coupled receptor, FFAR2, inducing the secretion of interleukin-8/IL-8. Binds preferentially to 9-O-acetylated 2-6-linked sialic acid derivatives and to various glycans containing sialic acid engaged in a 2-3 linkage. [UniProt]
细胞定位Secreted, Cell membrane, Peripheral membrane protein, Extracellular side. [UniProt]
预测分子量35 kDa
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