anti-GAD2 / GAD65 antibody
CAT.NO. : ARG40855
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概述
产品描述 | Mouse Monoclonal antibody recognizes GAD2 / GAD65 |
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反应物种 | Hu, Rat |
应用 | WB |
宿主 | Mouse |
克隆 | Monoclonal |
同位型 | IgG2b |
靶点名称 | GAD2 / GAD65 |
抗原物种 | Human |
抗原 | Purified recombinant Human GAD2 protein fragments. |
偶联标记 | Un-conjugated |
別名 | Glutamate decarboxylase 65 kDa isoform; EC 4.1.1.15; GAD65; 65 kDa glutamic acid decarboxylase; GAD-65; Glutamate decarboxylase 2 |
应用说明
应用建议 |
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应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
形式 | Liquid |
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纯化 | Affinity purified. |
缓冲液 | PBS (pH 7.4), 0.03% Proclin 300 and 50% Glycerol. |
抗菌剂 | 0.03% Proclin 300 |
稳定剂 | 50% Glycerol |
存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
数据库连接 | |
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基因名称 | GAD2 |
全名 | glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa) |
背景介绍 | This gene encodes one of several forms of glutamic acid decarboxylase, identified as a major autoantigen in insulin-dependent diabetes. The enzyme encoded is responsible for catalyzing the production of gamma-aminobutyric acid from L-glutamic acid. A pathogenic role for this enzyme has been identified in the human pancreas since it has been identified as an autoantibody and an autoreactive T cell target in insulin-dependent diabetes. This gene may also play a role in the stiff man syndrome. Alternative splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq, Oct 2008] |
生物功能 | Catalyzes the production of GABA. [UniProt] |
细胞定位 | Cytoplasm, cytosol. Cytoplasmic vesicle. Cell junction, synapse, presynaptic cell membrane; Lipid-anchor. Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side. Note=Associated to cytoplasmic vesicles. In neurons, cytosolic leaflet of Golgi membranes and presynaptic clusters. [UniProt] |
预测分子量 | 65 kDa |
翻译后修饰 | Phosphorylated; which does not affect kinetic parameters or subcellular location. Palmitoylated; which is required for presynaptic clustering. [UniProt] |
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