anti-GAD2 / GAD65 antibody

Key features and details

  • 产品描述: Mouse Monoclonal antibody recognizes GAD2 / GAD65
  • 反应物种: Hu, Rat
  • 应用: WB
  • 宿主: Mouse
  • 克隆: Monoclonal
  • 同位型: IgG2b
  • 靶点名称: GAD2 / GAD65
  • 抗原物种: Human
  • 抗原: Purified recombinant Human GAD2 protein fragments.
  • Brand:
CAT.NO. : ARG40855
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Product Details
概述
产品描述Mouse Monoclonal antibody recognizes GAD2 / GAD65
反应物种Hu, Rat
应用WB
宿主Mouse
克隆Monoclonal
同位型IgG2b
靶点名称GAD2 / GAD65
抗原物种Human
抗原Purified recombinant Human GAD2 protein fragments.
偶联标记Un-conjugated
別名Glutamate decarboxylase 65 kDa isoform; EC 4.1.1.15; GAD65; 65 kDa glutamic acid decarboxylase; GAD-65; Glutamate decarboxylase 2
应用说明
应用建议
应用推荐稀释比
WB1:1000
应用说明* The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.
属性
形式Liquid
纯化Affinity purified.
缓冲液PBS (pH 7.4), 0.03% Proclin 300 and 50% Glycerol.
抗菌剂0.03% Proclin 300
稳定剂50% Glycerol
存放说明For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
注意事项For laboratory research only, not for drug, diagnostic or other use.
生物信息
数据库连接

GeneID: 24380 Rat GAD2

GeneID: 2572 Human GAD2

Swiss-port # Q05329 Human Glutamate decarboxylase 2

Swiss-port # Q05683 Rat Glutamate decarboxylase 2

基因名称GAD2
全名glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa)
背景介绍This gene encodes one of several forms of glutamic acid decarboxylase, identified as a major autoantigen in insulin-dependent diabetes. The enzyme encoded is responsible for catalyzing the production of gamma-aminobutyric acid from L-glutamic acid. A pathogenic role for this enzyme has been identified in the human pancreas since it has been identified as an autoantibody and an autoreactive T cell target in insulin-dependent diabetes. This gene may also play a role in the stiff man syndrome. Alternative splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq, Oct 2008]
生物功能Catalyzes the production of GABA. [UniProt]
细胞定位Cytoplasm, cytosol. Cytoplasmic vesicle. Cell junction, synapse, presynaptic cell membrane; Lipid-anchor. Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side. Note=Associated to cytoplasmic vesicles. In neurons, cytosolic leaflet of Golgi membranes and presynaptic clusters. [UniProt]
预测分子量65 kDa
翻译后修饰Phosphorylated; which does not affect kinetic parameters or subcellular location.

Palmitoylated; which is required for presynaptic clustering. [UniProt]
检测图片 (1)
  • ARG40855 anti-GAD2 / GAD65antibody WB image

    Western blot: Rat hippocampus lysate stained with ARG40855 anti-GAD2 / GAD65antibody at 1:1000 dilution.

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