anti-GluR2 / 3 antibody

Key features and details

  • 产品描述: Rabbit Polyclonal antibody recognizes GluR2 / 3
  • 反应物种: Rat
  • 预测物种: Hu, Ms, Chk, Zfsh
  • 应用: WB
  • 宿主: Rabbit
  • 克隆: Polyclonal
  • 同位型: IgG
  • 靶点名称: GluR2 / 3
  • 抗原物种: Rat
  • Brand:
CAT.NO. : ARG52318
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Product Details
概述
产品描述Rabbit Polyclonal antibody recognizes GluR2 / 3
反应物种Rat
预测物种Hu, Ms, Chk, Zfsh
应用WB
宿主Rabbit
克隆Polyclonal
同位型IgG
靶点名称GluR2 / 3
抗原物种Rat
抗原Synthetic peptide corresponding to amino acid residues from the C-terminal region conjugated to KLH
偶联标记Un-conjugated
別名AMPA-selective glutamate receptor 2; GluA2; GluR-K2; Glutamate receptor ionotropic, AMPA 2; GluR-2; HBGR2; GLUR2; GluR-B; Glutamate receptor 2; GLURB
应用说明
应用建议
应用推荐稀释比
WB1:1,000
应用说明Specific for the ~100k GluR2/3 protein.
* The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.
属性
形式Liquid
纯化Affinity Purified
缓冲液10 mM HEPES (pH 7.5), 150 mM NaCl, 0.1 mg/ml BSA and 50% Glycerol
稳定剂0.1 mg/ml BSA, 50% Glycerol
存放说明For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
注意事项For laboratory research only, not for drug, diagnostic or other use.
生物信息
数据库连接

GeneID: 29627 Rat GRIA2

Swiss-port # P19491 Rat Glutamate receptor 2

基因名称GRIA2/3
全名glutamate receptor, ionotropic, AMPA 2
背景介绍The ion channels activated by glutamate are typically divided into two classes. Those that are sensitive to N-methyl-D-aspartate (NMDA) are designated NMDA receptors (NMDAR) while those activated by α-amino-3-hydroxy-5-methyl-4-isoxalone propionic acid (AMPA) are known as AMPA receptors (AMPAR). The AMPAR are comprised of four distinct glutamate receptor subunits designated (GluR1-4) and they play key roles in virtually all excitatory neurotransmission in the brain (Keinänen et al., 1990;Hollmann and Heinemann, 1994). The GluR2 subunit is widely expressed throughout the nervous system where it is thought to play key roles in synaptic plasticity and learning and memory (Duprat et al., 2003;Seidenman et al., 2003;Chung et al., 2003;Yan et al., 2002).
研究领域Neuroscience antibody
预测分子量99 kDa
翻译后修饰Palmitoylated. Depalmitoylated upon glutamate stimulation. Cys-610 palmitoylation leads to Golgi retention and decreased cell surface expression. In contrast, Cys-836 palmitoylation does not affect cell surface expression but regulates stimulation-dependent endocytosis (By similarity).
检测图片 (1)
  • ARG52318 anti-GluR2/3 antibody WB image

    Western Blot: rat hippocampal lysate showing specific immunolabeling of the ~100k GluR2/3 protein stained with GluR2/3 antibody (ARG52318).

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