anti-GRIK2 / GluK2 antibody
Key features and details
- 产品描述:
- 反应物种:
- 应用:
- 宿主:
- 克隆:
- 同位型:
- 靶点名称:
- 抗原物种:
- 抗原:
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Brand:
CAT.NO. : ARG42640
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Size:
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Product Details
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes GRIK2 / GluK2 |
|---|---|
| 反应物种 | Hu, Ms, Rat |
| 应用 | IHC-P, WB |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | GRIK2 / GluK2 |
| 抗原物种 | Human |
| 抗原 | Synthetic peptide derived from Human GRIK2 / GluK2. |
| 偶联标记 | Un-conjugated |
| 別名 | GLUK6; Glutamate receptor ionotropic, kainate 2; GluK2; Excitatory amino acid receptor 4; GLUR6; GluR-6; EAA4; MRT6; GLR6; Glutamate receptor 6; GluR6 |
应用说明
| 应用建议 |
| ||||||
|---|---|---|---|---|---|---|---|
| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||
| 阳性对照 | 293T | ||||||
| 实际分子量 | ~ 97 kDa |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Affinity purified. |
| 缓冲液 | PBS (pH 7.3), 0.02% Sodium azide, 50% Glycerol and 1% BSA. |
| 抗菌剂 | 0.02% Sodium azide |
| 稳定剂 | 50% Glycerol and 1% BSA |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | Swiss-port # P42260 Rat Glutamate receptor ionotropic, kainate 2 Swiss-port # Q13002 Human Glutamate receptor ionotropic, kainate 2 |
|---|---|
| 基因名称 | GRIK2 |
| 全名 | glutamate receptor, ionotropic, kainate 2 |
| 背景介绍 | Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. This gene product belongs to the kainate family of glutamate receptors, which are composed of four subunits and function as ligand-activated ion channels. The subunit encoded by this gene is subject to RNA editing at multiple sites within the first and second transmembrane domains, which is thought to alter the structure and function of the receptor complex. Alternatively spliced transcript variants encoding different isoforms have also been described for this gene. Mutations in this gene have been associated with autosomal recessive cognitive disability. [provided by RefSeq, Jul 2008] |
| 生物功能 | Ionotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist (PubMed:28180184). May be involved in the transmission of light information from the retina to the hypothalamus. Modulates cell surface expression of NETO2 (By similarity). [UniProt] |
| 预测分子量 | 103 kDa |
检测图片 (3)
ARG42640 anti-GRIK2 / GluK2 antibody IHC-P image
Immunohistochemistry: Paraffin-embedded Human lung cancer tissue stained with ARG42640 anti-GRIK2 / GluK2 antibody at 1:100 dilution.
ARG42640 anti-GRIK2 / GluK2 antibody WB image
Western blot: 25 µg of 293T cell lysate stained with ARG42640 anti-GRIK2 / GluK2 antibody at 1:1000 dilution.
ARG42640 anti-GRIK2 / GluK2 antibody IHC-P image
Immunohistochemistry: Paraffin-embedded Mouse kidney tissue stained with ARG42640 anti-GRIK2 / GluK2 antibody at 1:100 dilution.
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