anti-GTF2IRD1 antibody
Key features and details
- 产品描述:
- 反应物种:
- 应用:
- 宿主:
- 克隆:
- 同位型:
- 靶点名称:
- 抗原物种:
- 抗原:
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Brand:
CAT.NO. : ARG41180
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Product Details
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes GTF2IRD1 |
|---|---|
| 反应物种 | Hu, Ms, Rat |
| 应用 | WB |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | GTF2IRD1 |
| 抗原物种 | Human |
| 抗原 | Recombinant fusion protein corresponding to aa. 660-959 of Human GTF2IRD1 (NP_057412.1). |
| 偶联标记 | Un-conjugated |
| 別名 | WBSCR11; RBAP2; WBSCR12; BEN; WBS; Williams-Beuren syndrome chromosomal region 11 protein; Williams-Beuren syndrome chromosomal region 12 protein; GTF2I repeat domain-containing protein 1; Slow-muscle-fiber enhancer-binding protein; MUSTRD1; USE B1-binding protein; General transcription factor II-I repeat domain-containing protein 1; GTF3; CREAM1; MusTRD1/BEN; hMusTRD1alpha1; General transcription factor III; Muscle TFII-I repeat domain-containing protein 1 |
应用说明
| 应用建议 |
| ||||
|---|---|---|---|---|---|
| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||
| 阳性对照 | BT-474 | ||||
| 实际分子量 | 110 kDa |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Affinity purified. |
| 缓冲液 | PBS (pH 7.3), 0.02% Sodium azide and 50% Glycerol. |
| 抗菌剂 | 0.02% Sodium azide |
| 稳定剂 | 50% Glycerol |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | Swiss-port # Q9JI57 Mouse General transcription factor II-I repeat domain-containing protein 1 Swiss-port # Q9UHL9 Human General transcription factor II-I repeat domain-containing protein 1 |
|---|---|
| 基因名称 | GTF2IRD1 |
| 全名 | GTF2I repeat domain containing 1 |
| 背景介绍 | The protein encoded by this gene contains five GTF2I-like repeats and each repeat possesses a potential helix-loop-helix (HLH) motif. It may have the ability to interact with other HLH-proteins and function as a transcription factor or as a positive transcriptional regulator under the control of Retinoblastoma protein. This gene plays a role in craniofacial and cognitive development and mutations have been associated with Williams-Beuren syndrome, a multisystem developmental disorder caused by deletion of multiple genes at 7q11.23. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2010] |
| 生物功能 | May be a transcription regulator involved in cell-cycle progression and skeletal muscle differentiation. May repress GTF2I transcriptional functions, by preventing its nuclear residency, or by inhibiting its transcriptional activation. May contribute to slow-twitch fiber type specificity during myogenesis and in regenerating muscles. Binds troponin I slow-muscle fiber enhancer (USE B1). Binds specifically and with high affinity to the EFG sequences derived from the early enhancer of HOXC8 (By similarity). [UniProt] |
| 细胞定位 | Nucleus. [UniProt] |
| 预测分子量 | 106 kDa |
检测图片 (1)
ARG41180 anti-GTF2IRD1 antibody WB image
Western blot: 25 µg of BT-474 cell lysate stained with ARG41180 anti-GTF2IRD1 antibody at 1:1000 dilution.
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