anti-Histone H4 monomethyl (Lys12) antibody [RM458]
![anti-Histone H4 monomethyl (Lys12) antibody [RM458]](/upload/image/20241105/8415bc38bc270b898ee2a90369a6c7fb.jpg)
Key features and details
- 产品描述:
- 反应物种:
- 应用:
- 特异性:
- 宿主:
- 克隆:
- 克隆号:
- 同位型:
- 靶点名称:
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Brand:
CAT.NO. : ARG45030
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Product Details
概述
| 产品描述 | Rabbit monoclonal antibody recognizes Histone H4 monomethyl (Lys12). |
|---|---|
| 反应物种 | Hu |
| 应用 | ELISA, WB |
| 特异性 | This antibody reacts to Histone H4 monomethylated at Lysine 12 (K12me1). No cross reactivity with non-modified Lysine 12, or other monomethylations in histone H4. |
| 宿主 | Rabbit |
| 克隆 | Monoclonal |
| 克隆号 | RM458 |
| 同位型 | IgG |
| 靶点名称 | Histone H4 |
| 抗原物种 | Human |
| 抗原 | A monomethyl-peptide corresponding to monomethyl-Histone H4 (Lys12). |
| 偶联标记 | Un-conjugated |
| 別名 | H4C1; H4 Clustered Histone 1; HIST1H4A; H4FA; Histone Cluster 1 H4 Family Member A; H4 Histone Family, Member A; Histone Cluster 1, H4a; Histone 1, H4a; Histone H4; H4-16; HIST1H4B; HIST1H4C; HIST1H4D; HIST1H4E HIST1H4F; HIST1H4H; HIST1H4I; HIST1H4J; HIST1H4K; HIST1H4L; HIST2H4A; HIST2H4B; HIST2H4; HIST4H4; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4/A; H4/I; H4FI; H4/G; H4FG; H4/B; H4FB; H4/J; H4FJ; H4/C; H4FC; H4/H; H4FH H4/M; H4FM; H4/E; H4FE; H4/D; H4FD; H4/K; H4FK; H4/N; H4F2; H4FN; H4/O; H4FO |
应用说明
| 应用建议 |
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|---|---|---|---|---|---|---|---|
| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Purification with Protein A. |
| 缓冲液 | PBS with 50% Glycerol, 1% BSA and 0.09% sodium azide |
| 抗菌剂 | 0.09% sodium azide |
| 稳定剂 | 50% Glycerol, 1% BSA and 0.09% |
| 浓度 | 1 mg/ml |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
生物信息
| 基因名称 | H4C1 |
|---|---|
| 全名 | H4 Clustered Histone 1 |
| 背景介绍 | Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H4 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6. [provided by RefSeq, Aug 2015] |
| 生物功能 | Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. [Uniprot] |
| 细胞定位 | Chromosome, Nucleosome core, Nucleus. [Uniprot] |
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