anti-HLA ABC antibody [W6/32]

Key features and details

  • 产品描述: Mouse Monoclonal antibody [W6/32] recognizes HLA ABC
  • 反应物种: Hu, Bb, R. Mk
  • 应用: CyTOF®-candidate, FACS, IHC-Fr, IP
  • 特异性: The monoclonal antibody reacts with the human major histocompatibility complex (MHC) class I, HLA-A, B, C. MHC class I antigens associated with beta 2-microglobulin are expressed by all human nucleated cells and are central in cell-mediated immune response and tumor surveillance. The monoclonal antibody recognizes a non-polymorphic epitope shared among products of the HLA-A, B, and C loci and immunoprecipitates both 43 kDa and 11-12 kDa chains.Crossreactivity is also seen in baboon, rhesus and cynomolgus monkey.
  • 宿主: Mouse
  • 克隆: Monoclonal
  • 克隆号: W6/32
  • 同位型: IgG2a
  • 靶点名称: HLA ABC
  • Brand:
CAT.NO. : ARG65833
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Product Details
概述
产品描述Mouse Monoclonal antibody [W6/32] recognizes HLA ABC
反应物种Hu, Bb, R. Mk
应用CyTOF®-candidate, FACS, IHC-Fr, IP
特异性The monoclonal antibody reacts with the human major histocompatibility complex (MHC) class I, HLA-A, B, C. MHC class I antigens associated with beta 2-microglobulin are expressed by all human nucleated cells and are central in cell-mediated immune response and tumor surveillance. The monoclonal antibody recognizes a non-polymorphic epitope shared among products of the HLA-A, B, and C loci and immunoprecipitates both 43 kDa and 11-12 kDa chains.
Crossreactivity is also seen in baboon, rhesus and cynomolgus monkey.
宿主Mouse
克隆Monoclonal
克隆号W6/32
同位型IgG2a
靶点名称HLA ABC
抗原物种Human
抗原Human HLA ABC
偶联标记Un-conjugated
別名MHC class I antigen A*1; HLAA; HLA class I histocompatibility antigen, A-1 alpha chain
应用说明
应用建议
应用推荐稀释比
CyTOF®-candidateAssay-dependent
FACS10 µl/10^6 cells or 100 µl whole blood.
IHC-FrAssay-dependent
IPAssay-dependent
应用说明* The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.
属性
形式Liquid
纯化Purification with Protein A.
缓冲液PBS (pH 7.2) and 0.09% Sodium azide.
抗菌剂0.09% Sodium azide
浓度1 mg/ml
存放说明For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
注意事项For laboratory research only, not for drug, diagnostic or other use.
生物信息
数据库连接

GeneID: 3105 Human HLA-A

Swiss-port # P30443 Human HLA class I histocompatibility antigen, A-1 alpha chain

基因名称HLA-A
全名major histocompatibility complex, class I, A
背景介绍HLA-A belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. Class I molecules play a central role in the immune system by presenting peptides derived from the endoplasmic reticulum lumen. They are expressed in nearly all cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon 1 encodes the leader peptide, exons 2 and 3 encode the alpha1 and alpha2 domains, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region, and exons 6 and 7 encode the cytoplasmic tail. Polymorphisms within exon 2 and exon 3 are responsible for the peptide binding specificity of each class one molecule. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. Hundreds of HLA-A alleles have been described. [provided by RefSeq, Jul 2008]
生物功能Involved in the presentation of foreign antigens to the immune system. [UniProt]
产品亮点Related products:
HLA ABC antibodies; Anti-Mouse IgG secondary antibodies;
Related news:
CyTOF-candidate Antibodies
预测分子量41 kDa and 11-12 kDa chains
翻译后修饰Polyubiquitinated in a post ER compartment by interaction with human herpesvirus 8 MIR1 protein. This targets the protein for rapid degradation via the ubiquitin system (By similarity).
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