anti-HLA G antibody [MEM-G/1]
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Key features and details
- 产品描述:
- 反应物种:
- 应用:
- 特异性:
- 宿主:
- 克隆:
- 克隆号:
- 同位型:
- 靶点名称:
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Brand:
CAT.NO. : ARG10105
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Product Details
概述
| 产品描述 | Mouse Monoclonal antibody [MEM-G/1] recognizes HLA G |
|---|---|
| 反应物种 | Hu |
| 应用 | IHC-Fr, IHC-P, WB |
| 特异性 | The clone MEM-G/1 reacts with denaturated HLA-G heavy chain. HLA-G belongs to the MHC Class I molecules (MHC Class Ib; nonclassical) and it is expressed on the surface of trophoblast cells. |
| 宿主 | Mouse |
| 克隆 | Monoclonal |
| 克隆号 | MEM-G/1 |
| 同位型 | IgG1 |
| 靶点名称 | HLA G |
| 抗原物种 | Human |
| 抗原 | Denatured bacterially expressed recombinant human HLA-G heavy chain. |
| 偶联标记 | Un-conjugated |
| 別名 | HLA G antigen; MHC class I antigen G; HLA class I histocompatibility antigen, alpha chain G; MHC-G |
应用说明
| 应用建议 |
| ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 应用说明 | IHC-P: Incubated for 1 hour at RT. Staining technique: Standard ABC technique Pretreatment: Heat retrieval in 0.01M Citrate buffer (4x2 min. In microwave oven) * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||||
| 阳性对照 | IHC-P: Human placenta. |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Purified from ascites by protein-A affinity chromatography. |
| 纯度 | > 95% (by SDS-PAGE) |
| 缓冲液 | PBS (pH 7.4) and 15 mM Sodium azide |
| 抗菌剂 | 15 mM Sodium azide |
| 浓度 | 1 mg/ml |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | Swiss-port # P17693 Human HLA class I histocompatibility antigen, alpha chain G |
|---|---|
| 基因名称 | HLA-G |
| 全名 | major histocompatibility complex, class I, G |
| 背景介绍 | HLA-G belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. HLA-G is expressed on fetal derived placental cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the alpha1 and alpha2 domain, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region, and exon 6 encodes the cytoplasmic tail. [provided by RefSeq, Jul 2008] |
| 生物功能 | Involved in the presentation of foreign antigens to the immune system. Plays a role in maternal tolerance of the fetus by mediating protection from the deleterious effects of natural killer cells, cytotoxic T-lymphocytes, macrophages and mononuclear cells. [UniProt] |
| 研究领域 | Immune System antibody |
| 预测分子量 | 38 kDa |
检测图片 (2)
ARG10105 anti-HLA G antibody [MEM-G/1] IHC-P image
Immunohistochemistry: Pulmonary disseases (paraffin-embedded sections) stained with ARG10105 anti-HLA G antibody [MEM-G/1].
ARG10105 anti-HLA G antibody [MEM-G/1] IHC-P image
Immunohistochemistry: First-trimester placenta (paraffin-embedded sections) stained with ARG10105 anti-HLA G antibody [MEM-G/1].
参考文献
克隆号文献
Differential expression of β-catenin and Dickkopf-1 in the third trimester placentas from normal and preeclamptic pregnancies: a comparative study.
IHC / Human
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