anti-IDH2 antibody
Key features and details
- 产品描述:
- 反应物种:
- 预测物种:
- 应用:
- 宿主:
- 克隆:
- 同位型:
- 靶点名称:
- 抗原物种:
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Brand:
CAT.NO. : ARG55897
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Product Details
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes IDH2 |
|---|---|
| 反应物种 | Hu, Ms |
| 预测物种 | Rat |
| 应用 | ICC/IF, IHC-P, WB |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | IDH2 |
| 抗原物种 | Human |
| 抗原 | Synthetic peptide (17 aa) within the first 50 aa of Human IDH2. |
| 偶联标记 | Un-conjugated |
| 別名 | D2HGA2; IDH; Isocitrate dehydrogenase [NADP], mitochondrial; IDPM; EC 1.1.1.42; mNADP-IDH; ICD-M; IDP; IDHM; NADP; Oxalosuccinate decarboxylase |
应用说明
| 应用建议 |
| ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||||
| 阳性对照 | Human heart tissue lysate |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Affinity purification with immunogen. |
| 缓冲液 | PBS and 0.02% Sodium azide |
| 抗菌剂 | 0.02% Sodium azide |
| 浓度 | 1 mg/ml |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | Swiss-port # P48735 Human Isocitrate dehydrogenase [NADP], mitochondrial Swiss-port # P54071 Mouse Isocitrate dehydrogenase [NADP], mitochondrial |
|---|---|
| 基因名称 | IDH2 |
| 全名 | isocitrate dehydrogenase 2 (NADP+), mitochondrial |
| 背景介绍 | Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes belong to two distinct subclasses, one of which utilizes NAD(+) as the electron acceptor and the other NADP(+). Five isocitrate dehydrogenases have been reported: three NAD(+)-dependent isocitrate dehydrogenases, which localize to the mitochondrial matrix, and two NADP(+)-dependent isocitrate dehydrogenases, one of which is mitochondrial and the other predominantly cytosolic. Each NADP(+)-dependent isozyme is a homodimer. The protein encoded by this gene is the NADP(+)-dependent isocitrate dehydrogenase found in the mitochondria. It plays a role in intermediary metabolism and energy production. This protein may tightly associate or interact with the pyruvate dehydrogenase complex. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2014] |
| 生物功能 | Plays a role in intermediary metabolism and energy production. It may tightly associate or interact with the pyruvate dehydrogenase complex. [UniProt] |
| 预测分子量 | 51 kDa |
| 翻译后修饰 | Acetylation at Lys-413 dramatically reduces catalytic activity. Deacetylated by SIRT3. |
检测图片 (3)
ARG55897 anti-IDH2 antibody IHC-P image
Immunohistochemistry: Mouse heart tissue stained with ARG55897 anti-IDH2 antibody at 5 µg/ml dilution.
ARG55897 anti-IDH2 antibody WB image
Western blot: Human heart tissue lysate stained with ARG55897 anti-IDH2 antibody at (A) 1 and (B) 2 µg/ml dilution.
ARG55897 anti-IDH2 antibody IF image
Immunofluorescence: Mouse heart tissue stained with ARG55897 anti-IDH2 antibody at 20 µg/ml dilution.
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