anti-IL12B / IL12 p40 antibody
Key features and details
- 产品描述:
- 反应物种:
- 应用:
- 宿主:
- 克隆:
- 同位型:
- 靶点名称:
- 抗原物种:
- 抗原:
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Brand:
CAT.NO. : ARG64247
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Product Details
概述
| 产品描述 | Goat Polyclonal antibody recognizes IL12B / IL12 p40 |
|---|---|
| 反应物种 | Hu |
| 应用 | WB |
| 宿主 | Goat |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | IL12B / IL12 p40 |
| 抗原物种 | Human |
| 抗原 | C-QGKSKREKKDRVFTD |
| 偶联标记 | Un-conjugated |
| 別名 | CLMF; Interleukin-12 subunit beta; NK cell stimulatory factor chain 2; NKSF; CLMF p40; NKSF2; Cytotoxic lymphocyte maturation factor 40 kDa subunit; CLMF2; IL-12 subunit p40; IMD29; IMD28; IL-12B |
应用说明
| 应用建议 |
| ||||
|---|---|---|---|---|---|
| 应用说明 | WB: Recommend incubate at RT for 1h. * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| 缓冲液 | Tris saline (pH 7.3), 0.02% Sodium azide and 0.5% BSA |
| 抗菌剂 | 0.02% Sodium azide |
| 稳定剂 | 0.5% BSA |
| 浓度 | 0.5 mg/ml |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 背景介绍 | This gene encodes a subunit of interleukin 12, a cytokine that acts on T and natural killer cells, and has a broad array of biological activities. Interleukin 12 is a disulfide-linked heterodimer composed of the 40 kD cytokine receptor like subunit encoded by this gene, and a 35 kD subunit encoded by IL12A. This cytokine is expressed by activated macrophages that serve as an essential inducer of Th1 cells development. This cytokine has been found to be important for sustaining a sufficient number of memory/effector Th1 cells to mediate long-term protection to an intracellular pathogen. Overexpression of this gene was observed in the central nervous system of patients with multiple sclerosis (MS), suggesting a role of this cytokine in the pathogenesis of the disease. The promoter polymorphism of this gene has been reported to be associated with the severity of atopic and non-atopic asthma in children. [provided by RefSeq, Jul 2008] |
| 研究领域 | Cancer antibody; Immune System antibody |
| 预测分子量 | 37 kDa |
| 翻译后修饰 | Known to be C-mannosylated in the recombinant protein; it is not yet known for sure if the wild-type protein is also modified. |
检测图片 (2)
ARG64247 anti-IL12B / IL12 p40 antibody WB image
Western blot: Human Liver lysate (35 µg protein in RIPA buffer) stained with ARG64247 anti-IL12B / IL12 p40 antibody at 0.1 µg/ml dilution.
ARG64247 anti-IL12B / IL12 p40 antibody WB image
Western blot: 35 µg of Human liver (A), skin (B) and tonsil (C) lysates (in RIPA buffer) stained with ARG64247 anti-IL12B / IL12 p40 antibody at 0.3 µg/ml dilution and incubated at RT for 1 hour.
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