anti-ITGA8 antibody

Key features and details

  • 产品描述: Rabbit Polyclonal antibody recognizes ITGA8
  • 反应物种: Hu, Ms, Rat
  • 应用: WB
  • 宿主: Rabbit
  • 克隆: Polyclonal
  • 同位型: IgG
  • 靶点名称: ITGA8
  • 抗原物种: Human
  • 抗原: Recombinant fusion protein corresponding to aa. 907-1000 of Human ITGA8 (NP_003629.2).
  • Brand:
CAT.NO. : ARG59828
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Product Details
概述
产品描述Rabbit Polyclonal antibody recognizes ITGA8
反应物种Hu, Ms, Rat
应用WB
宿主Rabbit
克隆Polyclonal
同位型IgG
靶点名称ITGA8
抗原物种Human
抗原Recombinant fusion protein corresponding to aa. 907-1000 of Human ITGA8 (NP_003629.2).
偶联标记Un-conjugated
別名Integrin alpha-8
应用说明
应用建议
应用推荐稀释比
WB1:500 - 1:2000
应用说明* The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.
阳性对照Rat lung and Mouse spleen
实际分子量117 kDa
属性
形式Liquid
纯化Affinity purified.
缓冲液PBS (pH 7.3), 0.02% Sodium azide and 50% Glycerol.
抗菌剂0.02% Sodium azide
稳定剂50% Glycerol
存放说明For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
注意事项For laboratory research only, not for drug, diagnostic or other use.
生物信息
数据库连接

GeneID: 241226 Mouse ITGA8

GeneID: 8516 Human ITGA8

Swiss-port # A2ARA8 Mouse Integrin alpha-8

Swiss-port # P53708 Human Integrin alpha-8

基因名称ITGA8
全名integrin, alpha 8
背景介绍Integrins are heterodimeric transmembrane receptor proteins that mediate numerous cellular processes including cell adhesion, cytoskeletal rearrangement, and activation of cell signaling pathways. Integrins are composed of alpha and beta subunits. This gene encodes the alpha 8 subunit of the heterodimeric integrin alpha8beta1 protein. The encoded protein is a single-pass type 1 membrane protein that contains multiple FG-GAP repeats. This repeat is predicted to fold into a beta propeller structure. This gene regulates the recruitment of mesenchymal cells into epithelial structures, mediates cell-cell interactions, and regulates neurite outgrowth of sensory and motor neurons. The integrin alpha8beta1 protein thus plays an important role in wound-healing and organogenesis. Mutations in this gene have been associated with renal hypodysplasia/aplasia-1 (RHDA1) and with several animal models of chronic kidney disease. Alternate splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Apr 2014]
生物功能Integrin alpha-8/beta-1 functions in the genesis of kidney and probably of other organs by regulating the recruitment of mesenchymal cells into epithelial structures. It recognizes the sequence R-G-D in a wide array of ligands including TNC, FN1, SPP1 TGFB1, TGFB3 and VTN. NPNT is probably its functional ligand in kidney genesis. Neuronal receptor for TNC it mediates cell-cell interactions and regulates neurite outgrowth of sensory and motor neurons. [UniProt]
细胞定位Membrane; Single-pass type I membrane protein. Cell membrane. [UniProt]
预测分子量117 kDa
检测图片 (1)
  • ARG59828 anti-ITGA8 antibody WB image

    Western blot: 25 µg of Rat lung and Mouse spleen lysates stained wtih ARG59828 anti-ITGA8 antibody at 1:3000 dilution.

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