anti-ITPK1 antibody
Key features and details
- 产品描述:
- 反应物种:
- 应用:
- 宿主:
- 克隆:
- 同位型:
- 靶点名称:
- 抗原物种:
- 抗原:
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Brand:
CAT.NO. : ARG40345
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Product Details
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes ITPK1 |
|---|---|
| 反应物种 | Hu, Ms, Rat |
| 应用 | WB |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | ITPK1 |
| 抗原物种 | Human |
| 抗原 | Recombinant fusion protein corresponding to aa. 185-414 of Human ITPK1 (NP_055031.2). |
| 偶联标记 | Un-conjugated |
| 別名 | 1,3,4; EC 2.7.1.159; Inositol 1,3,4-trisphosphate 5/6-kinase; Inositol-triphosphate 5/6-kinase; 3; Ins; Inositol-tetrakisphosphate 1-kinase; EC 2.7.1.134; ITRPK1 |
应用说明
| 应用建议 |
| ||||
|---|---|---|---|---|---|
| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||
| 阳性对照 | Rat brain, Mouse brain and HeLa | ||||
| 实际分子量 | 43 kDa |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Affinity purified. |
| 缓冲液 | PBS (pH 7.3), 0.02% Sodium azide and 50% Glycerol. |
| 抗菌剂 | 0.02% Sodium azide |
| 稳定剂 | 50% Glycerol |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | Swiss-port # Q13572 Human Inositol-tetrakisphosphate 1-kinase Swiss-port # Q8BYN3 Mouse Inositol-tetrakisphosphate 1-kinase |
|---|---|
| 基因名称 | ITPK1 |
| 全名 | inositol-tetrakisphosphate 1-kinase |
| 生物功能 | Kinase that can phosphorylate various inositol polyphosphate such as Ins(3,4,5,6)P4 or Ins(1,3,4)P3. Phosphorylates Ins(3,4,5,6)P4 at position 1 to form Ins(1,3,4,5,6)P5. This reaction is thought to have regulatory importance, since Ins(3,4,5,6)P4 is an inhibitor of plasma membrane Ca(2+)-activated Cl(-) channels, while Ins(1,3,4,5,6)P5 is not. Also phosphorylates Ins(1,3,4)P3 on O-5 and O-6 to form Ins(1,3,4,6)P4, an essential molecule in the hexakisphosphate (InsP6) pathway. Also acts as an inositol polyphosphate phosphatase that dephosphorylate Ins(1,3,4,5)P4 and Ins(1,3,4,6)P4 to Ins(1,3,4)P3, and Ins(1,3,4,5,6)P5 to Ins(3,4,5,6)P4. May also act as an isomerase that interconverts the inositol tetrakisphosphate isomers Ins(1,3,4,5)P4 and Ins(1,3,4,6)P4 in the presence of ADP and magnesium. Probably acts as the rate-limiting enzyme of the InsP6 pathway. Modifies TNF-alpha-induced apoptosis by interfering with the activation of TNFRSF1A-associated death domain. [UniProt] |
| 预测分子量 | 46 kDa |
| 翻译后修饰 | Acetylation by EP300 and CREBBP destabilizes ITPK1, and down-regulates enzymatic activity. Deacetylated by SIRT1. [UniProt] |
检测图片 (2)
ARG40345 anti-ITPK1 antibody WB image
Western blot: 25 µg of HeLa cell lysate stained with ARG40345 anti-ITPK1 antibody at 1:1000 dilution.
ARG40345 anti-ITPK1 antibody WB image
Western blot: 25 µg of Rat brain and Mouse brain lysates stained with ARG40345 anti-ITPK1 antibody at 1:1000 dilution.
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